He was murdered by alleged members of the Ku Klux Klan in a drive-by shooting on Wednesday, June 2, 1965. He was driving home from work, when a pickup truck pulled up alongside. An occupant in the truck shot at Moore and his partner, Creed Rogers, another African-American deputy sheriff. Rogers survived the shooting with injuries, and broadcast a description of the pickup truck on the police radio. Moore had been receiving threats since joining the force, but stayed on the job. Rogers completed a career in law enforcement.
Two suspects in the shooting were arrested in Mississippi not long afterward. One was Ernest Ray McElveen, a known white supremacist. The police filed no charges due to a lack of evidence and witnesses. The cold case was reopened in a new investigation by the FBI in 1990, 2001, and 2007, but they did not bring indictments. McElveen, the prime suspect in the case, died in 2003.
The Deacons for Defense and Justice, an African-American group organized in Louisiana and elsewhere in the South to protect civil rights workers by armed defense, provided protection and support for Moore's widow.
- Officer Down Memorial Page for Oneal Moore
- FBI "Wanted" page for Information on the murder of Oneal Moore
- Oneal Moore at Find a Grave
- BBC - FBI reopens file on race hate murders
- Alison Shay, "On This Day: The Courage of Deputies Moore and Rogers", 2 June 2012, The Long Civil Rights Movement website