Nucleoside oxidase

Nucleoside oxidase
Identifiers
EC number 1.1.3.28
CAS number 82599-71-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Nucleoside oxidase (EC 1.1.3.28) is an enzyme with systematic name nucleoside:oxygen 5'-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

inosine + O2 9-riburonosylhypoxanthine + H2O
(1a) 2 inosine + O2 2 5'-dehydroinosine + 2 H2O
(1b) 2 5'-dehydroinosine + O2 2 9-riburonosylhypoxanthine

This enzyme could use other purine and pyrimidine nucleosides (as well as 2'-deoxynucleosides) are substrates.

References

  1. Isono, Y.; Sudo, T.; Hoshino, M. (1989). "Purification and reaction of a new enzyme, nucleoside oxidase". Agric. Biol. Chem. 53: 1663–1669. doi:10.1271/bbb1961.53.1663.
  2. Isono, Y.; Sudo, T.; Hoshino, M. (1989). "Properties of a new enzyme, nucleoside oxidase, from Pseudomonas maltophilia LB-86". Agric. Biol. Chem. 53: 1671–1677. doi:10.1271/bbb1961.53.1671.
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