|Trade names||Levarterenol, Levophed, Norepin|
|ATC code||C01CA03 (WHO)|
|Chemical and physical data|
|Molar mass||169.18 g/mol|
|3D model (Jmol)||Interactive image|
|Melting point||217 °C (423 °F) (decomposes)|
|Boiling point||442.6 °C (828.7 °F) ±40.0°C|
Norepinephrine, also known as noradrenaline, is a medication used to treat people with very low blood pressure. It is manufactured with the same formulation as the hormone and neurotransmitter norepinephrine. It is given intravenously.
Norepinephrine is used mainly as a sympathomimetic drug to treat people in vasodilatory shock states such as septic shock and neurogenic shock, while showing fewer adverse side-effects compared to dopamine treatment.
Mechanism of action
It acts on both α1 and α2 adrenergic receptors to cause blood vessel contraction. Its effects are often limited to the increasing of blood pressure through agonist activity on α1 and α2 receptors, and causing a resultant increase in peripheral vascular resistance.