Nicholas Hastie

Nicholas Hastie
Born Nicholas Dixon Hastie
(1947-03-29) 29 March 1947 [1]
Institutions
Alma mater
Thesis The role of the nucleus in influenza virus replication (1973)
Notable awards
Website
www.hgu.mrc.ac.uk/people/n.hastie.html

Professor Nicholas Dixon Hastie (born 1947) CBE, FRS, FRSE is a British geneticist, and Director of the MRC Human Genetics Unit at the University of Edinburgh.[2][3][4][5][6][7][8][9][10]

Education

Hastie was educated at the University of Liverpool and the University of Cambridge.[11]

Awards and honours

Hastie was elected a Fellow of the Royal Society in 2002. His nomination reads

“ Distinguished for his original and varied contributions to mammalian developmental genetics, genome organisation and gene expression. His early work established the abundance of messenger RNAs during mouse development, and led to the cloning of several genes that are expressed specifically in the liver. Further studies of the serpin gene family uncovered the first clear example of "accelerated protein evolution". At this time he also identified several novel repetitive elements in the mouse genome. His group was the first to characterise mammalian telomeres, and to demonstrate telomere shortening with age in man. Nick Hastie's current work is focused on human developmental mutations, notably Wilm's Tumour and Aniridia. His group demonstrated that aniridia, and the mouse equivalent, smalleye, are caused by mutations in the PAX6 gene. He continues to make incisive contributions to our understanding of the role of WT1, the candidate Wilm's Tumour gene, in development of the kidney and gonad.[12] ”

Hastie was also a member of the Faculty of 1000.[13]

References

  1. ↑ "HASTIE, Prof. Nicholas Dixon Anne". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
  2. ↑ http://www.hgu.mrc.ac.uk/people/n.hastie.html
  3. ↑ http://www.hgu.mrc.ac.uk/about_the_unit_section/director.html
  4. ↑ Hill, R. E.; Favor, J; Hogan, B. L.; Ton, C. C.; Saunders, G. F.; Hanson, I. M.; Prosser, J; Jordan, T; Hastie, N. D.; Van Heyningen, V (1991). "Mouse small eye results from mutations in a paired-like homeobox-containing gene". Nature. 354 (6354): 522–5. doi:10.1038/354522a0. PMID 1684639.
  5. ↑ Alan Wright, Nicholas Hastie, eds. (2007). Genes and common diseases. Cambridge University Press. ISBN 978-0-521-83339-4.
  6. ↑ Nicholas Hastie's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  7. ↑ Hastie, N. D.; Dempster, M.; Dunlop, M. G.; Thompson, A. M.; Green, D. K.; Allshire, R. C. (1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346 (6287): 866–8. doi:10.1038/346866a0. PMID 2392154.
  8. ↑ Teslovich, T. M.; Musunuru, K.; Smith, A. V.; Edmondson, A. C.; Stylianou, I. M.; Koseki, M.; Pirruccello, J. P.; Ripatti, S.; Chasman, D. I.; Willer, C. J.; Johansen, C. T.; Fouchier, S. W.; Isaacs, A.; Peloso, G. M.; Barbalic, M.; Ricketts, S. L.; Bis, J. C.; Aulchenko, Y. S.; Thorleifsson, G.; Feitosa, M. F.; Chambers, J.; Orho-Melander, M.; Melander, O.; Johnson, T.; Li, X.; Guo, X.; Li, M.; Shin Cho, Y.; Jin Go, M.; et al. (2010). "Biological, clinical and population relevance of 95 loci for blood lipids". Nature. 466 (7307): 707–13. doi:10.1038/nature09270. PMC 3039276Freely accessible. PMID 20686565.
  9. ↑ Pritchard-Jones, K; Fleming, S; Davidson, D; Bickmore, W; Porteous, D; Gosden, C; Bard, J; Buckler, A; Pelletier, J; Housman, D; Van Heyningen, Veronica; Hastie, Nicholas (1990). "The candidate Wilms' tumour gene is involved in genitourinary development". Nature. 346 (6280): 194–7. doi:10.1038/346194a0. PMID 2164159.
  10. ↑ Hastie, N (2012). "Linking genetics with biology in disease research: An interview with Nick Hastie". Disease Models & Mechanisms. 5 (2): 151–4. doi:10.1242/dmm.009605. PMC 3291636Freely accessible. PMID 22382364.
  11. ↑ Hastie, Nicholas (1973). The role of the nucleus in influenza virus replication (PhD thesis). University of Cambridge.
  12. ↑ "EC/2002/13: Hastie, Nicholas Dixon". London: The Royal Society. Archived from the original on 2014-03-31.
  13. ↑ http://f1000.com/thefaculty/member/1997201914387413
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