N2a cell

N2a cells (also known as Neuro2a cells) are a fast-growing mouse neuroblastoma cell line.[1] It is possible to differentiate N2a cells into cells that have many properties of neurons, including neurofilaments. N2a cells have been used to study neurite outgrowth,[1] neurotoxicity,[2] Alzheimer's disease,[3] and asymmetric division of mammalian cell lines.[4]

References

  1. 1 2 Salto R, Vílchez JD, Girón MD, Cabrera E, Campos N, Manzano M, Rueda R, López-Pedrosa JM (August 2015). "β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells". PLoS ONE. 10 (8): e0135614. doi:10.1371/journal.pone.0135614. PMC 4534402Freely accessible. PMID 26267903.
  2. ↑ LePage KT, Dickey RW, Gerwick WH, Jester EL, Murray TF (2005). "On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies". Critical Reviews in Neurobiology. 17 (1): 27–50. doi:10.1615/critrevneurobiol.v17.i1.20. PMID 16307526.
  3. ↑ Provost P (2010). "Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases". Aging. 2 (3): 166–169. doi:10.18632/aging.100131. PMC 871245Freely accessible. PMID 20375468.
  4. ↑ Ogrodnik M, Salmonowicz H, Brown R, Turkowska J, Sredniawa W, Pattabiraman S, Amen T, Abraham AC, Eichler N, Lyakhovetsky R, Kaganovich D (2014). "Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin". Proceedings of the National Academy of Sciences of the United States of America. 111 (22): 8049–54. doi:10.1073/pnas.1324035111. PMC 4050583Freely accessible. PMID 24843142.

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