Clinical data
Trade names Ethmozine
AHFS/ Consumer Drug Information
MedlinePlus a601214
ATC code C01BG01 (WHO)
Pharmacokinetic data
Bioavailability 34–38%
Protein binding 95%
Biological half-life 3–4 hours (healthy volunteers), 6–13 hours (cardiac disease)
CAS Number 31883-05-3 YesY
PubChem (CID) 34633
DrugBank DB00680 N
ChemSpider 31872 YesY
KEGG D05077 YesY
ECHA InfoCard 100.046.216
Chemical and physical data
Formula C22H25N3O4S
Molar mass 427.518 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Moracizine (INN[1]) or moricizine (USAN) (trade name Ethmozine) is an antiarrhythmic of class IC.[2] It was used for the prophylaxis and treatment of serious and life-threatening ventricular arrhythmias,[3] but was withdrawn in 2007 for commercial reasons.[4]


Moracizine, a phenothiazine derivative, undergoes extensive first-pass metabolism and is also extensively metabolized after it has entered the circulation. It may have pharmacologically active metabolites. A clinical study has shown that moracizine is slightly less effective than encainide or flecainide in suppressing ventricular premature depolarizations. Compared with disopyramide and quinidine, moracizine was equally or more effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.

In the Cardiac Arrhythmia Suppression Trial (CAST), a large study testing the influence of antiarrhythmics on mortality, showed a statistically non-significant increase of mortality from 5.4 to 7.2% under moracizine. This is in line with other class IC antiarrhythmics.[5]


  1. "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). World Health Organization. 2009. p. 103.
  2. Ahmmed, G. U.; Hisatome, I.; Kurata, Y.; Makita, N.; Tanaka, Y.; Tanaka, H.; Okamura, T.; Sonoyama, K.; Furuse, Y.; Kato, M.; Yamamoto, Y.; Ogura, K.; Shimoyama, M.; Miake, J.; Sasaki, N.; Ogino, K.; Igawa, O.; Yoshida, A.; Shigemasa, C. (2002). "Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block". Vascular pharmacology. 38 (3): 131–141. doi:10.1016/S1537-1891(02)00213-6. PMID 12402511.
  3. British National Formulary (59th ed.). British Medical Journal Publishing Group, Pharmaceutical Press. 2010.
  4. "Shire Announces Ethmozine will be Available until December 31, 2007". Heart Rhythm Society.
  5. "Effect of the Antiarrhythmic Agent Moricizine on Survival after Myocardial Infarction". New England Journal of Medicine. 327 (4): 227–233. 1992. doi:10.1056/NEJM199207233270403. PMID 1377359.

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