Minichromosome maintenance
| MCM2/3/5 family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of MCM from archaeal M. Thermoautotrophicum.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | MCM | ||||||||
| Pfam | PF00493 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR001208 | ||||||||
| SMART | SM00350 | ||||||||
| PROSITE | PDOC00662 | ||||||||
| |||||||||
Potential role of Cdc6 at the initiation of DNA replication.[2]
Minichromosome maintenance protein complex (MCM) is a eukaryotic DNA helicase complex required for the process of DNA replication, specifically the formation and elongation of the replication fork. It is a hexamer of six related polypeptides (MCM2 through MCM7) that form a ring structure.[3][4][5] MCM is a component of the pre-replication complex that forms at the eukaryotic origin of replication.
Control of MCM activity in the cell is partly achieved by its sumoylation. During cell cycle levels of chromatin-bound MCM sumoylation oscillate, loss of MCM sumoylation occurs immediately before DNA replication[6] Increased expression level of MCM proteins is observed in cells of different cancer types. MCMs could be useful markers of cancer cell proliferation.[7][8]
See also
References
- ↑ Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS (March 2003). "The structure and function of MCM from archaeal M. Thermoautotrophicum". Nat. Struct. Biol. 10 (3): 160–7. doi:10.1038/nsb893. PMID 12548282.
- ↑ Borlado LR, Méndez J (February 2008). "CDC6: from DNA replication to cell cycle checkpoints and oncogenesis". Carcinogenesis. 29 (2): 237–43. doi:10.1093/carcin/bgm268. PMID 18048387.
- 1 2 Cortez D, Glick G, Elledge SJ (July 2004). "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases". Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10078–83. doi:10.1073/pnas.0403410101. PMC 454167
. PMID 15210935. - ↑ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM (April 2002). "Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus". J. Biol. Chem. 277 (14): 12118–27. doi:10.1074/jbc.M200091200. PMID 11821426.
- ↑ Brewster, Aaron; Chen, Xiaojiang (June 2010). "Insights into MCM functional mechanism: lessons learned from the archaeal MCM complex". Crit Rev Biochem Mol Biol. 45 (3): 243–256. doi:10.3109/10409238.2010.484836. PMC 2953368. PMID 20441442.
- ↑ Baumann, Kim (2016). "DNA replication: SUMO wrestling to get the timing right". Nature Reviews Molecular Cell Biology. 17 (3): 134–135. doi:10.1038/nrm.2016.15. ISSN 1471-0072.
- ↑ Valverde, Ludmila de F.; de Freitas, Raíza D.; Pereira, Thiago de A.; de Resende, Marina F.; Agra, Ivan M. G.; Dos Santos, Jean N.; Dos Reis, Mitermayer G.; Sales, Caroline B. S.; Gurgel Rocha, Clarissa A. (2016-06-02). "MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma". Applied Immunohistochemistry & Molecular Morphology. doi:10.1097/PAI.0000000000000397. ISSN 1533-4058. PMID 27258565.
- ↑ Nowinska, Katarzyna; Chmielewska, Magdalena; Piotrowska, Aleksandra; Pula, Bartosz; Pastuszewski, Wojciech; Krecicki, Tomasz; Podhorska-Okołow, Marzena; Zabel, Maciej; Dziegiel, Piotr (2016-02-01). "Correlation between levels of expression of minichromosome maintenance proteins, Ki-67 proliferation antigen and metallothionein I/II in laryngeal squamous cell cancer". International Journal of Oncology. 48 (2): 635–645. doi:10.3892/ijo.2015.3273. ISSN 1791-2423. PMID 26648405.
External links
- Humphries C (2001-01-12). "Molecular Bureaucrat Tied to Replication Approval Process". Focus. Harvard Medical, Dental, and Public Health Schools. Retrieved 2008-10-03.
- macromolecular structures of MCM at the EM Data Bank(EMDB)
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