Clinical data
Trade names ProMeris, Alverde
ATCvet code QP53AX25 (WHO)
CAS Number 139968-49-3
ChemSpider 16738643
ECHA InfoCard 100.107.480
Chemical and physical data
Formula C24H16F6N4O2
Molar mass 506.40 g/mol
3D model (Jmol) Interactive image

Metaflumizone is a semicarbazone insecticide indicated for the veterinary treatment of fleas and ticks, marketed under the brand name ProMeris. A discontinued variant of ProMeris, called ProMeris Duo or Promeris for Dogs, was indicated for canine use and was a formulated blend of metaflumizone and amitraz.[1] The metaflumizone-only formulation is waterproof and typically remain effective for 30–45 days in a cutaneous application at the base of the neck.

Similar insecticides

Metaflumizone is chemically similar to pyrazoline sodium channel blocker insecticides (SCBIs) discovered at Philips-Duphar in the early 1970s, but is less dangerous to mammals than earlier formulations.[2]


Metaflumizone works by blocking sodium channels in target insects, resulting in paralyzation associated with blocking nerve activity. Metaflumizone blocks sodium channels by binding selectively to the slow-inactivated state, which is characteristic of the SCBIs.[2] The toxin has been tested for efficacy against Spodoptera eridania moths[2] and is indicated for control of fleas and ticks. However, in a cross comparison with other veterinary flea control substances, Metaflumizone was not shown to result in a significant reduction in the number of engorged adult female Culex mosquitoes.[3] Therefore, its usefulness as a heartworm control treatment is likely to be insignificant when compared with comparable treatments such as selamectin that do impact the mosquito disease vector.

Adverse effects reported

In 2011, Pfizer Animal Care decided to cease production of Promeris Duo / Promeris for Dogs based on findings of a study which linked its use to an elevated incidence of the autoimmune disorder pemphigus foliaceus.[4]


  1. PetPlace Drug Library
  2. 1 2 3 Salgado, VL; Hayashi, JH (2007). "Metaflumizone is a novel sodium channel blocker insecticide". Veterinary parasitology. 150 (3): 182–9. doi:10.1016/j.vetpar.2007.08.032. PMID 17959312.
  3. Bouhsira, E; Fysikopoulos, A; Franc, M (2009). "Efficacy of fipronil-(S)-methoprene, metaflumizone combined with amitraz, and pyriprole commercial spot-on products in preventing Culex pipiens pipiens from feeding on dogs". Veterinary Record. 165 (5): 135–7. doi:10.1136/vr.165.5.135. PMID 19648637.
  4. Jessica Tremayne (18 April 2011). "Study Links ProMeris to Pemphigus Foliaceus; Pfizer Stopping Its Production". Veterinary Practice News. California, United States: BowTie. Retrieved 26 April 2011.
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