Membrane-type matrix metalloproteinase-1
| Membrane-type matrix metalloproteinase-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.80 | ||||||||
| CAS number | 161384-17-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Membrane-type matrix metalloproteinase-1 (EC 3.4.24.80, matrix metalloproteinase 14) is an enzyme.[1] This enzyme catalyses the following chemical reaction
- Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-Leu. Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn341-Phe, Asp441-Leu and Gln354-Thr in the aggrecan interglobular domain
This enzyme belongs to peptidase family M10.
See also
References
- ↑ Itoh, Y.; Takamura, A.; Ito, N.; Maru, Y.; Sato, H.; Suenaga, N.; Aoki, T.; Seiki, M. (2001). "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion". EMBO J. 20: 4782–4793. doi:10.1093/emboj/20.17.4782. PMID 11532942.
External links
- Membrane-type matrix metalloproteinase-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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