Melanocortin 3 receptor

Aliases MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL, Melanocortin 3 receptor
External IDs MGI: 96929 HomoloGene: 7412 GeneCards: MC3R
Targeted by Drug
afamelanotide, Gamma-Melanocyte-stimulating hormone, MT-II[1]
RNA expression pattern
More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 56.25 – 56.25 Mb Chr 2: 172.25 – 172.25 Mb
PubMed search [2] [3]
View/Edit HumanView/Edit Mouse

Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.[4][5]


This gene encodes MC3, a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis.[5]

See also


  1. "Drugs that physically interact with Melanocortin receptor 3 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (Apr 1993). "Molecular cloning of a novel melanocortin receptor". The Journal of Biological Chemistry. 268 (11): 8246–50. PMID 8463333.
  5. 1 2 "Entrez Gene: MC3R melanocortin 3 receptor".

Further reading

  • Magenis RE, Smith L, Nadeau JH, Johnson KR, Mountjoy KG, Cone RD (Aug 1994). "Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human". Mammalian Genome. 5 (8): 503–8. doi:10.1007/BF00369320. PMID 7949735. 
  • Konda Y, Gantz I, DelValle J, Shimoto Y, Miwa H, Yamada T (May 1994). "Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor". The Journal of Biological Chemistry. 269 (18): 13162–6. PMID 8175743. 
  • Gantz I, Tashiro T, Barcroft C, Konda Y, Shimoto Y, Miwa H, Glover T, Munzert G, Yamada T (Oct 1993). "Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 18 (1): 166–7. doi:10.1006/geno.1993.1448. PMID 8276410. 
  • Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (Mar 1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Molecular Endocrinology. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374. 
  • Tota MR, Smith TS, Mao C, MacNeil T, Mosley RT, Van der Ploeg LH, Fong TM (Jan 1999). "Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors". Biochemistry. 38 (3): 897–904. doi:10.1021/bi9815602. PMID 9893984. 
  • McNulty JC, Thompson DA, Bolin KA, Wilken J, Barsh GS, Millhauser GL (Dec 2001). "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein". Biochemistry. 40 (51): 15520–7. doi:10.1021/bi0117192. PMID 11747427. 
  • Lee YS, Poh LK, Loke KY (Mar 2002). "A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity". The Journal of Clinical Endocrinology and Metabolism. 87 (3): 1423–6. doi:10.1210/jc.87.3.1423. PMID 11889220. 
  • Qian S, Chen H, Weingarth D, Trumbauer ME, Novi DE, Guan X, Yu H, Shen Z, Feng Y, Frazier E, Chen A, Camacho RE, Shearman LP, Gopal-Truter S, MacNeil DJ, Van der Ploeg LH, Marsh DJ (Jul 2002). "Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice". Molecular and Cellular Biology. 22 (14): 5027–35. doi:10.1128/MCB.22.14.5027-5035.2002. PMC 139785Freely accessible. PMID 12077332. 
  • Boucher N, Lanouette CM, Larose M, Pérusse L, Bouchard C, Chagnon YC (Mar 2002). "A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence". Molecular Medicine. 8 (3): 158–65. PMC 2039979Freely accessible. PMID 12142547. 
  • Wong J, Love DR, Kyle C, Daniels A, White M, Stewart AW, Schnell AH, Elston RC, Holdaway IM, Mountjoy KG (Oct 2002). "Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes". Diabetes Research and Clinical Practice. 58 (1): 61–71. doi:10.1016/S0168-8227(02)00126-2. PMID 12161058. 
  • Rached M, Buronfosse A, Begeot M, Penhoat A (Aug 2004). "Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity". Biochimica et Biophysica Acta. 1689 (3): 229–34. doi:10.1016/j.bbadis.2004.03.009. PMID 15276649. 
  • Tao YX, Segaloff DL (Aug 2004). "Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation". The Journal of Clinical Endocrinology and Metabolism. 89 (8): 3936–42. doi:10.1210/jc.2004-0367. PMID 15292330. 
  • Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (Jan 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. 
  • Mandrika I, Petrovska R, Wikberg J (Jan 2005). "Melanocortin receptors form constitutive homo- and heterodimers". Biochemical and Biophysical Research Communications. 326 (2): 349–54. doi:10.1016/j.bbrc.2004.11.036. PMID 15582585. 
  • de Krom M, de Rijke CE, Hendriks J, van Engeland H, van Elburg AA, Adan RA (Dec 2005). "Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients". Psychiatric Genetics. 15 (4): 237. doi:10.1097/00041444-200512000-00003. PMID 16314751. 
  • Chen M, Aprahamian CJ, Celik A, Georgeson KE, Garvey WT, Harmon CM, Yang Y (Jan 2006). "Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction". Biochemistry. 45 (4): 1128–37. doi:10.1021/bi0521792. PMID 16430209. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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