Maitansine
 | |
| Names | |
|---|---|
| Other names
Maytansin | |
| Identifiers | |
35846-53-8  | |
| 3D model (Jmol) | Interactive image |
| ChEBI | CHEBI:6701  |
| ChEMBL | ChEMBL488931 |
| ECHA InfoCard | 100.047.944 |
| PubChem | 5281828 |
| UNII | 14083FR882 |
| |
| Properties | |
| C34H46ClN3O10 | |
| Molar mass | 692.20 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.[1]
It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus.[1]
Derivatives are known as maytansinoids.[2]
See also
- Mertansine, a derivative
References
- 1 2 National Cancer Institute: Definition of Maytansine
- ↑ Yu, T.-W.; Bai, L; Clade, D; Hoffmann, D; Toelzer, S; Trinh, KQ; Xu, J; Moss, SJ; Leistner, E (2002). "The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum". Proceedings of the National Academy of Sciences. 99 (12): 7968–7973. doi:10.1073/pnas.092697199. PMC 123004
. PMID 12060743.
This article is issued from Wikipedia - version of the 7/7/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.