Mantle zone

Mantle zone
Image labeled in German, but "Mantel-zone" visible near center.
*Anatomical terminology* [edit on Wikidata]

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.^[1]

It is also known as the "corona".^[2]

It contains transient lymphocytes.^[3]

It is the location of the lymphoma in mantle cell lymphoma.

Pathology

Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain.

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.

http://erl.pathology.iupui.edu/HISTO/LABE109.HTM
Histology image: 07102loa – Histology Learning System at Boston University — "Lymphoid Tissues and Organs: lymph node, cortex and medulla"

Bone marrow	Hematopoietic stem cell

Thymus	Cortex Medulla Hassall's corpuscles

Spleen	structural: Hilum Trabeculae Diaphragmatic surface of spleen Visceral surface of spleen Red pulp Cords of Billroth Marginal zone White pulp Periarteriolar lymphoid sheaths Germinal center blood flow: Trabecular arteries Trabecular veins

Tonsils	Palatine Lingual Pharyngeal Tubal Tonsillar crypts Waldeyer's tonsillar ring

Lymph nodes	lymph flow: Afferent lymph vessels Cortical sinuses Medullary sinuses Efferent lymph vessels T cells: High endothelial venules B cells: Primary follicle/Germinal center Mantle zone Marginal zone layers: Capsule/Trabeculae Subcapsular sinus Cortex Paracortex Medulla (Medullary cord) Hilum

MALT	GALT Peyer's patch Germinal center

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