MOS (gene)

MOS

Identifiers

MOS, MSV, v-mos Moloney murine sarcoma viral oncogene homolog

External IDs

MGI: 97052 HomoloGene: 3919 GeneCards: MOS

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • MAP kinase kinase kinase activity • ATP binding • kinase activity
Cellular component	• intracellular • cell
Biological process	• protein autophosphorylation • protein phosphorylation • activation of MAPK activity • establishment of meiotic spindle orientation • chromatin organization • meiotic spindle organization • phosphorylation • activation of MAPKK activity • negative regulation of metaphase/anaphase transition of meiotic cell cycle • MAPK cascade
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


4342


17451


ENSG00000172680


ENSMUSG00000078365


P00540


P00536

RefSeq (mRNA)


NM_005372


NM_020021

RefSeq (protein)


NP_005363.1


n/a

Location (UCSC)

Chr 8: 56.11 – 56.11 Mb

Chr 4: 3.87 – 3.87 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.^[3]^[4]

Interactions

MOS (gene) has been shown to interact with MyoD.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Singh B, Arlinghaus RB (May 1998). "Mos and the cell cycle". Prog Cell Cycle Res. 3: 251–9. doi:10.1007/978-1-4615-5371-7_20. PMID 9552420.
↑ "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog".
↑ Lenormand, J L; Benayoun B; Guillier M; Vandromme M; Leibovitch M P; Leibovitch S A (Feb 1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. UNITED STATES. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. ISSN 0270-7306. PMC 231783. PMID 9001211.

Further reading

Sagata N (1997). "What does Mos do in oocytes and somatic cells?". BioEssays. 19 (1): 13–21. doi:10.1002/bies.950190105. PMID 9008413.
Caubet JF, Mathieu-Mahul D, Bernheim A, et al. (1986). "Human proto-oncogene c-mos maps to 8q11.". EMBO J. 4 (9): 2245–8. PMC 554492. PMID 3000766.
Watson R, Oskarsson M, Vande Woude GF (1982). "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4078–82. doi:10.1073/pnas.79.13.4078. PMC 346580. PMID 6287464.
Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE (1995). "Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos.". Hum. Reprod. 10 (3): 699–707. PMID 7540181.
Lenormand JL, Benayoun B, Guillier M, et al. (1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.". Mol. Cell. Biol. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. PMC 231783. PMID 9001211.
Liu H, Vuyyuru VB, Pham CD, et al. (1999). "Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association.". Oncogene. 18 (23): 3461–70. doi:10.1038/sj.onc.1202699. PMID 10376524.
Pham CD, Vuyyuru VB, Yang Y, et al. (1999). "Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos.". Oncogene. 18 (30): 4287–94. doi:10.1038/sj.onc.1202804. PMID 10439036.
Proikas-Cezanne T, Stabel S, Riethmacher D (2002). "Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.". BMC Biochem. 3: 6. doi:10.1186/1471-2091-3-6. PMC 102758. PMID 12022922.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kalejs M, Ivanov A, Plakhins G, et al. (2006). "Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe.". BMC Cancer. 6: 6. doi:10.1186/1471-2407-6-6. PMC 1351196. PMID 16401344.

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