Aliases MAS1, MAS1 proto-oncogene, G protein-coupled receptor, MAS, MGRA
External IDs OMIM: 165180 MGI: 96918 HomoloGene: 1782 GeneCards: MAS1
RNA expression pattern
More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 159.91 – 159.92 Mb Chr 17: 12.84 – 12.87 Mb
PubMed search [1] [2]
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MAS proto-oncogene, or mas-related G-protein coupled receptor A (MRGA, MRGPRA, MRGPCRA), also proposed as the adenine receptor or P0 receptor, is a protein that in humans is encoded by the MAS1 gene.[3]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[3]

Agonists of the receptor include adenine and 8-aminoadenine.

See also


Further reading

  • Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". Journal of Cardiovascular Pharmacology. 18 Suppl 2: S7–13. doi:10.1097/00005344-199106182-00003. PMID 1725048. 
  • Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action". Ciba Foundation Symposium. 150: 23–38; discussion 38–46. PMID 2197067. 
  • Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (Jul 1987). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Research. 1 (2): 169–78. PMID 3329713. 
  • Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (Sep 1988). "The mas oncogene encodes an angiotensin receptor". Nature. 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518. 
  • Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (Jun 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. 
  • Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM (Jul 1996). "The MAS proto-oncogene is not imprinted in humans". Genomics. 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154. 
  • Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR (May 2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Experimental Neurology. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460. 
  • Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T (May 2002). "Cell type-specific expression of the Mas proto-oncogene in testis". The Journal of Histochemistry and Cytochemistry. 50 (5): 691–6. doi:10.1177/002215540205000510. PMID 11967280. 
  • Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (Jul 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMC 166216Freely accessible. PMID 12829792. 
  • Canals M, Jenkins L, Kellett E, Milligan G (Jun 2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". The Journal of Biological Chemistry. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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