Laminin, alpha 2

LAMA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases LAMA2, LAMM, Laminin, alpha 2, laminin subunit alpha 2
External IDs MGI: 99912 HomoloGene: 37306 GeneCards: LAMA2
Genetically Related Diseases
amyotrophic lateral sclerosis, refractive error[1]
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

3908

16773

Ensembl

ENSG00000196569

ENSMUSG00000019899

UniProt

P24043

Q60675

RefSeq (mRNA)

NM_000426
NM_001079823

NM_008481

RefSeq (protein)

NP_000417.2
NP_001073291.1

NP_032507.2

Location (UCSC) Chr 6: 128.88 – 129.52 Mb Chr 10: 26.98 – 27.62 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.[4][5][6]

Function

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.[6]

References

Further reading

External links


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