Janeway lesion

Janeway lesion
Classification and external resources
Specialty infectious disease
ICD-10 A41.8 (ILDS A41.820)

Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis.[1] Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1] They are caused by septic emboli which deposit bacteria, forming microabscesses.[2] Janeway lesions are distal, flat, ecchymotic, and painless.

Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness and are of immunologic origin.[3]

Eponym

They are named after Edward Janeway (1841-1911), a prominent American physician and pathologist who initially described the lesions.

See also

References

  1. 1 2 Farrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688.
  2. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone 2009.
  3. Farrior JB, Silverman ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688.
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