Isosorbide mononitrate

Isosorbide mononitrate
Clinical data
AHFS/ Consumer Drug Information
  • C (USA)
Routes of
ATC code C01DA14 (WHO)
Pharmacokinetic data
Bioavailability >95%
Protein binding <5%
Metabolism Hepatic
Biological half-life 5 hours
Excretion Renal (93%)
CAS Number 16051-77-7 YesY
PubChem (CID) 27661
DrugBank DB01020 YesY
ChemSpider 25736 YesY
UNII LX1OH63030 YesY
KEGG D00630 YesY
ECHA InfoCard 100.036.527
Chemical and physical data
Formula C6H9NO6
Molar mass 191.139 g/mol
3D model (Jmol) Interactive image

Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris[1] and acts by dilating the blood vessels so as to reduce the blood pressure. It is sold in the USA by Kremers Urban under the trade name Monoket, also sold in the USA under the name Imdur, and marketed in the UK under the trade names: Monosorb, Chemydur. In India, this drug is available under the brand names of Ismo, Isonorm, Monotrate, Solotrate, and Monit. In Russia it is occasionally used under the brand names Monocinque and Pektrol.


Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Research on isosorbide mononitrate as a cervical ripener to reduce time at hospital to birth is supportive.[2]


The adverse reactions, which follow, have been reported in studies with isosorbide mononitrate:

Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3% of patients, but the incidence reduces rapidly as treatment continues .

Common: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified-release tablets, but at a frequency no greater than for placebo. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%).

Adverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. They occur mainly in the early stages of treatment.

Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. In general, these symptoms disappear during long-term treatment.

Other reactions that have been reported with isosorbide mononitrate modified-release tablets include tachycardia, vomiting, diarrhoea, vertigo, and heartburn.



  1. Imdur (isosorbide-5-mononitrate) is a nitrate preparation for angina pectoris, AstraZeneca Cardiovascular]
  2. Shrikant Bollapragada; Fiona Mackenzie; John Norrie; Stavros Petrou; Margaret Reid; Ian Greer; Inass Osman; Jane E Norman (2006). "IMOP: randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour – clinical trial with analyses of efficacy, cost effectiveness and acceptability". BMC Pregnancy and Childbirth. 6: 25. doi:10.1186/1471-2393-6-25. PMC 1569865Freely accessible. PMID 16869966.
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