Clinical data
AHFS/ International Drug Names
ATC code D01AC05 (WHO) G01AF07 (WHO)
CAS Number 27523-40-6
PubChem (CID) 3760
DrugBank DB08943 N
ChemSpider 3629
KEGG D04624
ChEBI CHEBI:82865 YesY
ECHA InfoCard 100.044.084
Chemical and physical data
Formula C18H14Cl4N2O
Molar mass 416.127 g/mol
3D model (Jmol) Interactive image

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.[1][2] Nigerian and British medical researchers found that for foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.[3][4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.[1]


  1. 1 2 Veraldi, Stefano (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 Suppl 1: 3–15. doi:10.1111/myc.12054. ISSN 1439-0507. PMID 23574019.
  2. The Merck Index, 12th Edition, 5176
  3. Oyeka, C.A.; Gugnani H.C. (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes.". Mycoses. 35 (11-12): 357–61. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811.
  4. Cohen, L. (1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole.". Retrieved 2008-05-23.

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