Irreversible agonist

An irreversible agonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. It is distinct from a mere (reversible) agonist in that the association of an agonist to a receptor is reversible, whereas the binding of an irreversible agonist to a receptor is, at least in theory, irreversible. Oxymorphazone is an example of an irreversible agonist.[1] In practice, the distinction may be more a matter of degree, in which the binding affinity of an irreversible agonist is some orders of magnitude greater than that of an agonist.


See also


  1. Galetta S, Ling GS, Wolfin L, Pasternak GW (Sep 1982), "Receptor binding and analgesic properties of oxymorphazone", Life Sciences, 31 (12-13): 1389–92, doi:10.1016/0024-3205(82)90388-5, PMID 6183551
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