Interstitial collagenase
| Interstitial collagenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
collagenase monomer, Human fibroblast | |||||||||
| Identifiers | |||||||||
| EC number | 3.4.24.7 | ||||||||
| CAS number | 2593923 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Interstitial collagenase (EC 3.4.24.7, vertebrate collagenase, matrix metalloproteinase 1) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
This enzyme belongs to the peptidase family M10.
See also
References
- ↑ Goldberg, G.I.; Wilhelm, S.M.; Kronberger, A.; Bauer, E.A.; Grant, G.A.; Eisen, A.Z. (1986). "Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein". J. Biol. Chem. 261: 6600–6605. PMID 3009463.
- ↑ Birkedal-Hansen, H. (1987). "Catabolism and turnover of collagens: collagenases". Methods Enzymol. 144: 140–171. doi:10.1016/0076-6879(87)44177-3. PMID 3041177.
- ↑ Fields, G.B.; Van Wart, H.E.; Birkedal-Hansen, H. (1987). "Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site". J. Biol. Chem. 262: 6221–6226. PMID 3032960.
- ↑ Sottrup-Jensen, L.; Birkedal-Hansen, H. (1989). "Human fibroblast collagenase-α-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian α-macroglobulins". J. Biol. Chem. 264: 393–401. PMID 2462561.
External links
- Interstitial collagenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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