Interleukin-18 receptor
| interleukin 18 receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | IL18R1 |
| Alt. symbols | IL1RRP, IL-1Rrp, CD218a |
| Entrez | 8809 |
| HUGO | 5988 |
| OMIM | 604494 |
| RefSeq | NM_003855 |
| UniProt | Q13478 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 18 receptor accessory protein | |
|---|---|
| Identifiers | |
| Symbol | IL18RAP |
| Alt. symbols | AcPL, CD218b |
| Entrez | 8807 |
| HUGO | 5989 |
| OMIM | 604509 |
| RefSeq | NM_003853 |
| UniProt | O95256 |
| Other data | |
| Locus | Chr. 2 p24.3-24.1 |
The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.[1][2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.
Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.[3]
References
- ↑ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.
- ↑ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.
- ↑ Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility. 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.
External links
- Receptors, Interleukin-18 at the US National Library of Medicine Medical Subject Headings (MeSH)
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