Inositol-polyphosphate multikinase

Inositol-polyphosphate multikinase
Identifiers
EC number 2.7.1.151
CAS number 9077-69-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.

References

  1. Saiardi, A.; Erdjument-Bromage, H.; Snowman, A.M.; Tempst, P.; Snyder, S.H. (1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr. Biol. 9: 1323–1326. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
  2. Odom, A.R.; Stahlberg, A.; Wente, S.R.; York, J.D. (2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control". Science. 287 (5460): 2026–2029. doi:10.1126/science.287.5460.2026. PMID 10720331.
  3. Stevenson-Paulik, J.; Odom, A.R.; York, J.D. (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277: 42711–42718. doi:10.1074/jbc.M209112200. PMID 12226109.
  4. Verbsky, J.W.; Chang, S.C.; Wilson, M.P.; Mochizuki, Y.; Majerus, P.W. (2005). "The pathway for the production of inositol hexakisphosphate in human cells". J. Biol. Chem. 280 (3): 1911–1920. doi:10.1074/jbc.M411528200. PMID 15531582.
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