Cutaneous small-vessel vasculitis

Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis", "Cutaneous leukocytoclastic vasculitis", "Cutaneous necrotizing venulitis" and "Hypersensitivity angiitis")[1] is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura.[2]:831[3] It is the most common vasculitis seen in clinical practice.

Leukocytoclasis refers to the damage caused by nuclear debris from infiltrating neutrophils in and around the vessels.[4]

Subtypes of small-vessel vasculitis include:[2]:833–6

Leukocytoclastic vasculitis

See also


  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  2. 1 2 James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  3. Lotti T, Ghersetich I, Comacchi C, Jorizzo JL (November 1998). "Cutaneous small-vessel vasculitis". J. Am. Acad. Dermatol. 39 (5 Pt 1): 667–87; quiz 688–90. doi:10.1016/S0190-9622(98)70039-8. PMID 9810883.
  4. Harrison's Principles of Internal Medicine. 18th edition. Page 2798.
  5. J. C. Jennette; R. J. Falk; P. A. Bacon; et al. (January 2013). "2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides". Arthritis & Rheumatism. 65 (1): 1–11. doi:10.1002/art.37715. PMID 23045170.

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