Granzyme A
| Granzyme A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.78 | ||||||||
| CAS number | 143180-73-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Granzyme A (EC 3.4.21.78, CTLA3, HuTPS, T-cell associated protease 1, cytotoxic T lymphocyte serine protease, TSP-1, T-cell derived serine proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-, -Lys- >> -Phe- in small molecule substrates
This enzyme is present in cytotoxic T lymphocyte granules.
See also
References
- ↑ Simon, M.M.; Hoschützky, H.; Fruth, U.; Simon, H.-G.; Kramer, M.D. (1986). "Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes". EMBO J. 5 (12): 3267–3274. PMID 3545816.
- ↑ Gershenfeld, H.K.; Hershberger, R.J.; Shows, T.B.; Weissman, I.L. (1988). "Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease". Proc. Natl. Acad. Sci. USA. 85: 1184–1188. doi:10.1073/pnas.85.4.1184. PMC 279731
. PMID 3257574. - ↑ Odake, S.; Kam, C.-M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C. (1991). "Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins". Biochemistry. 30 (8): 2217–2227. doi:10.1021/bi00222a027. PMID 1998680.
External links
- Granzyme A at the US National Library of Medicine Medical Subject Headings (MeSH)
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