Glycyl endopeptidase

Glycyl endopeptidase
Identifiers
EC number 3.4.22.25
CAS number 149719-24-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya proteinase 4, PPIV, chymopapain M) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Preferential cleavage: Gly-, in proteins and small molecule substrates

This enzyme is isolated from the papaya plant, Carica papaya.

References

  1. Polgár, L. (1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochim. Biophys. Acta. 658: 262–269. doi:10.1016/0005-2744(81)90296-5. PMID 7018581.
  2. Buttle, D.J.; Kembhavi, A.A.; Sharp, S.L.; Shute, R.E.; Rich, D.H.; Barrett, A.J. (1989). "Affinity purification of the novel cysteine proteinase papaya proteinase IV and papain from papaya latex". Biochem. J. 261: 469–476. PMID 2505761.
  3. Ritonja, A.; Buttle, D.J.; Rawlings, N.D.; Turk, V.; Barrett, A.J. (1989). "Papaya proteinase IV amino acid sequence". FEBS Lett. 258: 109–112. doi:10.1016/0014-5793(89)81627-8. PMID 2591528.
  4. Buttle, D.J.; Ritonja, A.; Pearl, L.H.; Turk, V.; Barrett, A.J. (1990). "Selective cleavage of glycyl bonds by papaya proteinase IV". FEBS Lett. 260: 195–197. doi:10.1016/0014-5793(90)80101-n. PMID 2404797.
  5. Buttle, D.J.; Ritonja, A.; Dando, P.M.; Abrahamson, M.; Shaw, E.N.; Wikstrom, P.; Turk, V.; Barrett, A.J. (1990). "Interaction of papaya proteinase IV with inhibitors". FEBS Lett. 262: 58–60. doi:10.1016/0014-5793(90)80153-a. PMID 1690669.
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