Gilean McVean

Gil McVean

Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute (WTSI), Hinxton.
Born Gilean Alistair Tristram McVean
February 1973 (age 43)[1]
Alma mater
Thesis Adaptation and conflict : the differences between the sexes in mammalian genome evolution (1998)
Doctoral advisor Laurence Hurst[2][3][4]
Other academic advisors
Doctoral students
  • Iain Mathieson [5]
  • Adam Auton
  • Bartu Ahiska
  • Niall Cardin
  • Ella Chase
  • Jo Gay
  • Chris Hallsworth
  • Loukas Moutsianas[6]
  • Chris Spencer
  • Daniel Wilson[7]
Notable awards

Gilean Alistair Tristram McVean (born 1973)[1] FRS[9] FMedSci is a professor of statistical genetics at the University of Oxford,[10] director of the Big Data Institute,[11] fellow of Linacre College, Oxford and co-founder and director at Genomics plc[1][12] He also co-chaired the 1000 Genomes Project analysis group.[13][14]


From [15][16] McVean completed his PhD in the Department of Genetics, at the University of Cambridge supervised by Laurence Hurst[17][18] in 1998.[3][19]

Career and research

Following his PhD, McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000 supervised by Brian Charlesworth and Deborah Charlesworth.[20][21] From 2000-2004 he was a Royal Society University Research Fellow, in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004 (reappointed in 2009 until retirement age).[22] In October 2006 he was appointed professor of statistical genetics at the University of Oxford.[23]

His research[24] focuses on population genetics, statistics[25] and evolutionary biology including the International HapMap Project,[26][27] recombination rates in the human genome[28] and the 1000 Genomes Project.[29][30] He developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[31]

In 2014 with Peter Donnelly he co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[1]

He was appointed as acting director of the Big Data Institute at the University of Oxford.[11]

Honours and awards

In 2006 he was awarded a Philip Leverhulme Prize.[32][33]

In 2010 McVean was awarded the Francis Crick Medal and delivered that years lecture entitled "Our genomes, our history".[34]

In 2012 McVean was awarded the Weldon Memorial Prize.[35]

In 2013 McVean presented at TEDxWarwick with a talk entitled A Thousand Genomes a Thousand Stories.[36]

In may of 2014 McVean was elected as a member of the European Molecular Biology Organisation.[37]

McVean was elected Fellow of the Royal Society (FRS) in 2016[9] and a Fellow of the Academy of Medical Sciences (FMedSci).[38][39]


  1. 1 2 3 4 Anon (2016). "Gilean MCVEAN Date of birth: February 1973". London: Companies House. Archived from the original on 2016-08-12.
  2. Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current Biology. 6 (5): 533–536. doi:10.1016/S0960-9822(02)00535-3. PMID 8805261.
  3. 1 2 McVean, Gilean Alistair Tristram (1998). Adaptation and conflict : the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge. OCLC 894602716.
  4. "Students and post-docs past and present in the Hurst laboratory". University of Bath. Archived from the original on 2015-05-15.
  5. Matieson, Iain (2013). Genes in space: Selection, association and variation in spatially structured populations. (PDF) (DPhil thesis). University of Oxford.
  6. Moutsianas, Loukas (2011). Imputation aided analysis of the association between autoimmune diseases and the MHC (DPhil thesis). University of Oxford. OCLC 820778016.
  7. McVean, Gil (2016). "McVean Group". Oxford: University of Oxford. Archived from the original on 2016-03-04.
  8. Crick Lectures
  9. 1 2 Anon (2016). "Gilean McVean". London: Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
  10. McVean Group at the University of Oxford
  11. 1 2 "Gil McVean — Oxford Big Data Institute". Retrieved 2016-07-12.
  12. "Prof. Gil McVean - GENOMICS plc". Retrieved 2016-07-12.
  13. "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics". Retrieved 2016-07-12.
  14. Gilean McVean publications from Europe PubMed Central
  15. "Gil McVean | LinkedIn". Retrieved 2016-07-12.
  16. Gil McVean's Entry at ORCID
  17. McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature. 386 (6623): 388–392. doi:10.1038/386388a0. PMID 9121553.
  18. Hurst, L.D.; McVean, G.T. (1996). "... And scandalous symbionts". Nature. 381 (6584): 650–651. doi:10.1038/381650a0. PMID 8649507.
  19. Gilean McVean Oxford University
  20. Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution. 16 (5): 235–242. doi:10.1016/S0169-5347(01)02126-7. PMID 11301152.
  21. "Oxford University Statistics | Professor Gilean McVean". Retrieved 2016-07-12.
  22. "Oxford University Gazette, 14 May 2009: Examinations and Boards". Retrieved 2016-07-12.
  23. "Oxford University Gazette". Retrieved 2016-07-12.
  24. Gilean McVean in Google Scholar
  25. Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M.; Sabeti, P. C. (2011). "Detecting Novel Associations in Large Data Sets". Science. 334 (6062): 1518–1524. doi:10.1126/science.1205438. PMC 3325791Freely accessible. PMID 22174245.
  26. Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; Zhang, H. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature. 449 (7164): 851–861. doi:10.1038/nature06258. PMC 2689609Freely accessible. PMID 17943122.
  27. Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; Gao, Yang (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature. 449 (7164): 913–918. doi:10.1038/nature06250. PMC 2687721Freely accessible. PMID 17943131.
  28. McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science. 304 (5670): 581–584. doi:10.1126/science.1092500. PMID 15105499.
  29. Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011). "The Variant Call Format and VCFtools". Bioinformatics. 27 (15): 2156–2158. doi:10.1093/bioinformatics/btr330. PMC 3137218Freely accessible. PMID 21653522.
  30. Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science. 331 (6019): 920–924. doi:10.1126/science.1198878. PMC 3669691Freely accessible. PMID 21330547.
  31. "Gilean McVean". Retrieved 2016-07-12.
  32. "AWARDS MADE IN 2006" (PDF). The Leverhulme Trust. 2006. Retrieved 2016-07-12.
  33. "Philip Leverhulme Prizes 2006" (PDF). The Leverhulme Trust. 2006. Retrieved 2016-07-12.
  34. The Royal Society (2013-12-10), Our genomes, our history, retrieved 2016-07-12
  35. "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics". Retrieved 2016-07-12.
  36. TEDx Talks (2013-03-29), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013, retrieved 2016-07-12
  37. User, Super. "EMBO enlarges its membership for 50th anniversary". Retrieved 2016-07-12.
  38. "New Fellows | Academy of Medical Sciences". Retrieved 2016-07-12.
  39. "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc". Retrieved 2016-07-12.
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