GTF2H5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YDL, 2JNJ, 5IY8, 5IY6, 5IY7, 5IVW, 5IY9

Identifiers

Aliases

GTF2H5, C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTDA, bA120J8.2, TTD3, general transcription factor IIH subunit 5

External IDs

MGI: 107227 HomoloGene: 45635 GeneCards: GTF2H5

Gene ontology
Molecular function	• rDNA binding
Cellular component	• nucleoplasm • nucleolus • core TFIIH complex • nucleus
Biological process	• termination of RNA polymerase I transcription • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • transcription, DNA-templated • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • transcription elongation from RNA polymerase I promoter • cellular response to gamma radiation • rRNA processing • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • nucleotide-excision repair, DNA incision • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA duplex unwinding • DNA repair • nucleotide-excision repair, preincision complex stabilization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


404672


66467

Ensembl


ENSG00000272047


ENSMUSG00000034345

UniProt


Q6ZYL4


Q8K2X8

RefSeq (mRNA)


NM_207118


NM_181392

RefSeq (protein)


NP_997001.1


NP_852057.2

Location (UCSC)

Chr 6: 158.17 – 158.2 Mb

Chr 17: 6.08 – 6.09 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

General transcription factor IIH subunit 5 is a protein that in humans is encoded by the GTF2H5 gene.^[3]^[4]

Interactions

GTF2H5 has been shown to interact with GTF2H2^[3]^[5] and XPB.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (June 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.
↑ "Entrez Gene: GTF2H5 general transcription factor IIH, polypeptide 5".
↑ Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (November 2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–13. doi:10.1038/81603. PMID 11062469.

Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–13. doi:10.1038/81603. PMID 11062469.
Coin F, Proietti De Santis L, Nardo T, Zlobinskaya O, Stefanini M, Egly JM (2006). "p8/TTD-A as a repair-specific TFIIH subunit". Mol. Cell. 21 (2): 215–26. doi:10.1016/j.molcel.2005.10.024. PMID 16427011.
Giglia-Mari G, Miquel C, Theil AF, Mari PO, Hoogstraten D, Ng JM, Dinant C, Hoeijmakers JH, Vermeulen W (2006). "Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells". PLoS Biol. 4 (6): e156. doi:10.1371/journal.pbio.0040156. PMC 1457016. PMID 16669699.
Vitorino M, Coin F, Zlobinskaya O, Atkinson RA, Moras D, Egly JM, Poterszman A, Kieffer B (2007). "Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy". J. Mol. Biol. 368 (2): 473–80. doi:10.1016/j.jmb.2007.02.020. PMID 17350038.

PDB gallery

1ydl: Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045.

2jnj: Solution structure of the p8 TFIIH subunit

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GTF2H5

Interactions

References

Further reading