GSK3A

GSK3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DFM
Identifiers
Aliases	GSK3A, Gsk3a, 2700086H06Rik
External IDs	MGI: 2152453 HomoloGene: 88581 GeneCards: GSK3A
EC number	2.7.11.1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein kinase A catalytic subunit binding • kinase activity • protein serine/threonine kinase activity • tau-protein kinase activity • protein binding • ATP binding Cellular component • cytosol • beta-catenin destruction complex • postsynapse • mitochondrion Biological process • positive regulation of cAMP biosynthetic process • insulin receptor signaling pathway • positive regulation of protein catabolic process • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • phosphorylation • positive regulation of protein targeting to mitochondrion • chemical synaptic transmission, postsynaptic • carbohydrate metabolic process • negative regulation of UDP-glucose catabolic process • negative regulation of type B pancreatic cell development • cardiac left ventricle morphogenesis • Wnt signaling pathway • negative regulation of glycogen biosynthetic process • nervous system development • negative regulation of glycogen synthase activity, transferring glucose-1-phosphate • dopamine receptor signaling pathway • protein phosphorylation • negative regulation of TOR signaling • IRE1-mediated unfolded protein response • positive regulation of heart contraction • negative regulation of glucose import • negative regulation of insulin receptor signaling pathway • negative regulation of cell growth involved in cardiac muscle cell development • regulation of mitophagy • negative regulation of glycogen (starch) synthase activity • regulation of systemic arterial blood pressure • extrinsic apoptotic signaling pathway in absence of ligand • cellular response to insulin stimulus • glycogen metabolic process • positive regulation of glycogen (starch) synthase activity • cellular response to interleukin-3 • negative regulation of signal transduction • positive regulation of adrenergic receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2931	606496
Ensembl	ENSG00000105723	ENSMUSG00000057177
UniProt	P49840	Q2NL51
RefSeq (mRNA)	NM_019884	NM_001031667
RefSeq (protein)	NP_063937.2	NP_001026837.1
Location (UCSC)	Chr 19: 42.23 – 42.24 Mb	Chr 7: 25.23 – 25.24 Mb
PubMed search	[1]	[2]
Wikidata

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.^[3]

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.^[4][5]

Model organisms

Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3a^{tm1a(EUCOMM)Wtsi[8][9]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[6][13] Twenty one tests were carried out on mutant mice but no significant abnormalities were observed.^[6]

See also

• Glycogen synthase kinase 3

References