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|ATC code||G01AX06 (WHO) QJ01XE90 (WHO)|
|Chemical and physical data|
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Furazolidone has been used in human and veterinary medicine. It has a broad spectrum of activity being active against
- Gram positive
- Gram negative
Use in humans
In humans it has been used to treat diarrhoea and enteritis caused by bacteria or protozoan infections. It has been used to treat traveler's diarrhoea, cholera and bacteremic salmonellosis. Use in treating Helicobacter pylori infections has also been proposed.
Use in animals
It has also been used in aquaculture.
Use in laboratory
It is believed to work by crosslinking of DNA.
Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, peripheral neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991.
- Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria. 84 (2): 160–5. doi:10.2223/JPED.1772. PMID 18372934.
- Petri WA (February 2005). "Treatment of Giardiasis". Curr Treat Options Gastroenterol. 8 (1): 13–17. doi:10.1007/s11938-005-0047-3. PMID 15625030.
- Meng J, Mangat SS, Grudzinski IP, Law FC (1998). "Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout". Drug Metabol Drug Interact. 14 (4): 209–19. PMID 10694929.
- Bagley, Clell. "Drugs Prohibited from Extralabel Use in Animals". Retrieved 14 April 2014.
- "DrugBank: Showing Furazolidone (DB00614)". Retrieved 2008-12-19.
- http://caraga.da.gov.ph/services/banmed-Nitrofurans.htm Archived September 24, 2007, at the Wayback Machine.