Felix Hoffmann (January 21, 1868 – February 8, 1946) was a German chemist notable for re-synthesizing diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin". He is also credited with synthesizing aspirin, though whether he did this under his own initiative or under the instruction of Arthur Eichengrün is highly contested.
Felix Hoffmann was born on January 21, 1868 in Ludwigsburg, the son of an industrialist. In 1889 he started studying chemistry at the Ludwig Maximilian University of Munich to study pharmacy and ended it in 1890 with the pharmaceutical state exam. In 1891 he graduated magna cum laude from the University of Munich. Two years later he earned his doctorate, also magna cum laude, after completing his thesis entitled "On certain derivatives of dihydroanthracene". In 1894, he joined Bayer as a research chemist.
On August 10, 1897, Hoffmann synthesized acetylsalicylic acid (ASA) while working at Bayer under Arthur Eichengrün. By acetylating salicylic acid with acetic acid, he succeeded in creating acetylsalicylic acid (ASA) in a chemically pure and stable form. The pharmacologist responsible for verifying these results was skeptical at first, yet once several large-scale studies to investigate the substance's efficacy and tolerability had been completed, it was found to be a pain-relieving, fever-lowering and anti-inflammatory substance. The company then worked to develop a cost-effective production process that would facilitate the promising active ingredient to be supplied as a pharmaceutical product. In 1899 it was marketed for the first time under the trade name Aspirin, initially as a powder supplied in glass bottles.
Hoffmann first claimed to be the inventor of aspirin (as opposed to just the synthesizer) in a footnote to a German encyclopedia published in 1934, saying that his father had complained about the bitter taste of sodium salicylate, the only drug then available to treat rheumatism. The large doses (6–8 grams) of sodium salicylate that were used to treat arthritis commonly irritated the stomach lining and caused patients considerable pain and irritation. He claimed that he began looking for a less acidic formation which led him to synthesize acetylsalicylic acid, a compound that shared the therapeutic properties of other salicylates but not the strong acidity that he believed caused stomach irritations.
Hoffman was never married and died without issue on February 8, 1946, in Switzerland.
An alternative credit for developing aspirin has also been offered. In 1949, ex-Bayer employee Arthur Eichengrün published a paper in which he claimed to have planned and directed Hoffman's synthesis of aspirin along with the synthesis of several related compounds. He also claimed to be responsible for aspirin's initial surreptitious clinical testing. Finally, he claimed that Hoffmann's role was restricted to the initial lab synthesis using his (Eichengrün's) process and nothing more.
The Eichengrün version was ignored by historians and chemists until 1999, when Walter Sneader of the Department of Pharmaceutical Sciences at the University of Strathclyde in Glasgow re-examined the case and came to the conclusion that indeed Eichengrün's account was convincing and correct and that Eichengrün deserved credit for the invention of aspirin. Bayer denied this in a press release, asserting that the invention of aspirin was due to Hoffmann.
In 2002, he was inducted into the US National Inventors Hall of Fame.
- "Felix Hoffmann". Bayer: Science for a better life. Retrieved 18 November 2016.
- "Felix Hoffmann". Chemical Heritage Foundation. Retrieved 18 November 2016.
- Goldberg, Daniel R. (2009). "Aspirin: Turn of the Century Miracle Drug". Chemical Heritage Magazine. Summer. Retrieved 18 November 2016.
- Eichengrün A. 50 Jahre Aspirin. Pharmazie 1949;4:582-4. (in German)
- Sneader, W (2000). "The discovery of aspirin: a reappraisal". BMJ (Clinical research ed.). 321 (7276): 1591–4. doi:10.1136/bmj.321.7276.1591. PMC 1119266. PMID 11124191.
- Sneader's paper crediting Eichengrün with the invention of aspirin in the British Medical Journal.
- Wer hat es erfunden? (Who invented it?) (German)