FIP1L1

Identifiers

FIP1L1, FIP1, Rhe, hFip1, factor interacting with PAPOLA and CPSF1

External IDs

Gene ontology
Molecular function	• poly(A) RNA binding • protein binding • RNA binding
Cellular component	• mRNA cleavage and polyadenylation specificity factor complex • nucleus • nucleoplasm
Biological process	• mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • mRNA 3'-end processing • mRNA export from nucleus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


81608


n/a

Ensembl


ENSG00000145216


n/a

UniProt


Q6UN15


n/a

RefSeq (mRNA)


NM_001134937 NM_001134938 NM_030917


n/a

RefSeq (protein)


NP_001128409.1 NP_001128410.1 NP_112179.2


n/a

Location (UCSC)

Chr 4: 53.38 – 53.46 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Pre-mRNA 3'-end-processing factor FIP1 is a protein that in humans is encoded by the FIP1L1 gene.^[2]^[3]

References

↑ "Human PubMed Reference:".
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ "Entrez Gene: FIP1L1 FIP1 like 1 (S. cerevisiae)".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cools J, DeAngelo DJ, Gotlib J, et al. (2003). "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.". N. Engl. J. Med. 348 (13): 1201–14. doi:10.1056/NEJMoa025217. PMID 12660384.
Griffin JH, Leung J, Bruner RJ, et al. (2003). "Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome.". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7830–5. doi:10.1073/pnas.0932698100. PMC 164673. PMID 12808148.
Pardanani A, Ketterling RP, Brockman SR, et al. (2004). "CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy.". Blood. 102 (9): 3093–6. doi:10.1182/blood-2003-05-1627. PMID 12842979.
Cools J, Quentmeier H, Huntly BJ, et al. (2004). "The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.". Blood. 103 (7): 2802–5. doi:10.1182/blood-2003-07-2479. PMID 14630792.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
Pardanani A, Brockman SR, Paternoster SF, et al. (2004). "FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia.". Blood. 104 (10): 3038–45. doi:10.1182/blood-2004-03-0787. PMID 15284118.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Zhao X, Oberg D, Rush M, et al. (2005). "A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein.". J. Virol. 79 (7): 4270–88. doi:10.1128/JVI.79.7.4270-4288.2005. PMC 1061554. PMID 15767428.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Cools J, Stover EH, Gilliland DG (2006). "Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia.". Methods Mol. Med. 125: 177–87. doi:10.1385/1-59745-017-0:177. PMID 16502585.
Stover EH, Chen J, Folens C, et al. (2006). "Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.". Proc. Natl. Acad. Sci. U.S.A. 103 (21): 8078–83. doi:10.1073/pnas.0601192103. PMC 1472432. PMID 16690743.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.

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FIP1L1

References

Further reading