FGI-106

FGI-106
Legal status

Legal status	Investigational New Drug
Identifiers
IUPAC name 1-N,7-N-bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine
CAS Number	501081-38-5^Y
PubChem (CID)	432342
ChemSpider	382357
Chemical and physical data
Formula	C₂₈H₃₈N₆
Molar mass	458.640
3D model (Jmol)	Interactive image
SMILES CN(C)CCCNc(c2ccc14)cc(C)nc2c1ccc3c4nc(C)cc3NCCCN(C)C
InChI InChI=1S/C28H38N6/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32) Key:WJUPENLNVUCETH-UHFFFAOYSA-N

FGI-106 is a broad-spectrum antiviral drug developed as a potential treatment for enveloped RNA viruses, in particular viral hemorrhagic fevers from the bunyavirus, flavivirus and filovirus families. It acts as an inhibitor which blocks viral entry into host cells. In animal tests FGI-106 shows both prophylactic and curative action against a range of deadly viruses for which few existing treatments are available, including the bunyaviruses Hantavirus, Rift Valley fever virus and Crimean-Congo hemorrhagic fever virus, the flavivirus Dengue virus, and the filoviruses Ebola virus and Marburg virus.^[1]^[2]^[3]^[4]^[5]

References

↑ Aman, M. J.; Kinch, M. S.; Warfield, K.; Warren, T.; Yunus, A.; Enterlein, S.; Stavale, E.; Wang, P.; Chang, S.; Tang, Q. (2009). "Development of a broad-spectrum antiviral with activity against Ebola virus". Antiviral Research. 83 (3): 245–251. doi:10.1016/j.antiviral.2009.06.001.
↑ Kinch (2010). "Development of FGI-106 as a broad-spectrum therapeutic with activity against members of the family Bunyaviridae". Virus Adaptation and Treatment: 9. doi:10.2147/VAAT.S6903.
↑ Basu, A.; Li, B.; Mills, D. M.; Panchal, R. G.; Cardinale, S. C.; Butler, M. M.; Peet, N. P.; Majgier-Baranowska, H.; Williams, J. D.; Patel, I.; Moir, D. T.; Bavari, S.; Ray, R.; Farzan, M. R.; Rong, L.; Bowlin, T. L. (2011). "Identification of a Small-Molecule Entry Inhibitor for Filoviruses". Journal of Virology. 85 (7): 3106–3119. doi:10.1128/JVI.01456-10.
↑ Ippolito, G.; Feldmann, H.; Lanini, S.; Vairo, F.; Di Caro, A.; Capobianchi, M.; Nicastri, E. (2012). "Viral hemorrhagic fevers: Advancing the level of treatment". BMC Medicine. 10: 31. doi:10.1186/1741-7015-10-31. PMC 3325866. PMID 22458265.
↑ Picazo E, Giordanetto F. Small molecule inhibitors of ebola virus infection. Drug Discovery Today February 2015, 20(2):277–286. doi:10.1016/j.drudis.2014.12.010

Ebolavirus

Species	Bundibugyo ebolavirus (BDBV) Reston ebolavirus (RESTV) Sudan ebolavirus (SUDV) Taï Forest ebolavirus (TAFV) Zaire ebolavirus (EBOV)

Outbreaks	List of Ebola outbreaks 1976 Sudan outbreak 1976 Zaire outbreak 2013−2016 West African Ebola virus epidemic Timeline Responses United Nations Ebola Response Fund Operation United Assistance in Guinea in Liberia in Mali in Sierra Leone in Spain in the United States in the United Kingdom Ouse to Ouse Tock Womey Massacre 2014 DR Congo outbreak

Drug candidates	BCX4430 Brincidofovir DZNep Favipiravir FGI-103 FGI-104 FGI-106 JK-05 Lamivudine Triazavirin ZMapp Vaccines cAd3-ZEBOV VSV-EBOV

Failed drug candidates	TKM-Ebola

Notable people	William Close Peter Piot Notable patients Ameyo Adadevoh Kent Brantly Pauline Cafferkey Thomas Eric Duncan Sheik Umar Khan Matthew Lukwiya Patrick Sawyer

In popular culture	The Hot Zone (1995 book) Outbreak (1995 film) Ebola Syndrome (1996 film) Executive Orders (1996 novel) 93 Days (2016 film)

Miscellaneous	Ebola virus disease Ebola River

Marburgvirus

Species	Marburg marburgvirus MARV RAVV

Drug candidates	BCX4430 FGI-103 FGI-106

In popular culture	The Hot Zone (1995 book)

Miscellaneous	Marburg virus disease Marburg

"Cuevavirus"
(proposed inclusion)

Species	"Lloviu cuevavirus" (LLOV)

NS3/4A protease inhibitors (–previr)	Asunaprevir Boceprevir Faldaprevir^‡ Grazoprevir Paritaprevir Simeprevir Telaprevir

NS5A inhibitors (–asvir)	Daclatasvir Elbasvir Ledipasvir MK-3682 MK-8408 Odalasvir^† Ombitasvir Ravidasvir^† Samatasvir^† Velpatasvir

NS5B RNA polymerase inhibitors (–buvir)	Beclabuvir^† Dasabuvir Deleobuvir^§ Filibuvir^§ Setrobuvir^§ Sofosbuvir Radalbuvir^†

Combination drugs	Elbasvir/grazoprevir Ledipasvir/sofosbuvir Ombitasvir/paritaprevir/ritonavir Sofosbuvir/daclatasvir Velpatasvir/sofosbuvir

Anti-influenza agents

Multiple/general

Interferon	Interferon alfa 2b Peginterferon alfa-2a^#

Multiple/unknown	BCX4430^† Favipiravir GS-5734^† Mericitabine^† MK-608^§ NITD008^§ Moroxydine Ribavirin^#/Taribavirin^† Triazavirin

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