Ezrin

EZR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RM8, 4RMA, 4RM9, 1NI2
Identifiers
Aliases	EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin
External IDs	MGI: 98931 HomoloGene: 55740 GeneCards: EZR
Gene ontology Molecular function • protein domain specific binding • protein complex binding • cytoskeletal protein binding • protein kinase A regulatory subunit binding • protein kinase A catalytic subunit binding • S100 protein binding • actin filament binding • protein binding • cell adhesion molecule binding • microtubule binding • ATPase binding • actin binding • poly(A) RNA binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • cytosol • endosome • membrane • focal adhesion • T-tubule • ruffle • Schwann cell microvillus • ruffle membrane • actin cytoskeleton • perinuclear region of cytoplasm • cytoskeleton • cell projection • cytoplasmic side of apical plasma membrane • myelin sheath • extracellular space • microvillus • microspike • nucleolus • apical plasma membrane • membrane raft • extracellular exosome • microvillus membrane • ciliary basal body • filopodium • cortical cytoskeleton • plasma membrane • apical part of cell • astrocyte projection • intracellular • cell cortex • brush border • actin filament • TCR signalosome • cell periphery • extrinsic component of membrane • cell body • vesicle • plasma membrane raft • uropod • basolateral plasma membrane • immunological synapse • cell tip • cell-cell adherens junction Biological process • leukocyte cell-cell adhesion • regulation of organelle assembly • sphingosine-1-phosphate signaling pathway • negative regulation of p38MAPK cascade • actin filament bundle assembly • establishment of epithelial cell apical/basal polarity • cytoskeletal anchoring at plasma membrane • positive regulation of multicellular organism growth • astral microtubule organization • cellular response to cAMP • establishment of endothelial barrier • microvillus assembly • positive regulation of cellular protein catabolic process • negative regulation of T cell receptor signaling pathway • positive regulation of establishment of protein localization to plasma membrane • gland morphogenesis • cortical microtubule organization • positive regulation of protein localization to early endosome • positive regulation of early endosome to late endosome transport • intestinal D-glucose absorption • establishment or maintenance of apical/basal cell polarity • regulation of NIK/NF-kappaB signaling • epithelial cell differentiation • regulation of actin cytoskeleton organization • negative regulation of interleukin-2 secretion • negative regulation of transcription from RNA polymerase II promoter • positive regulation of protein secretion • membrane to membrane docking • regulation of cell shape • protein kinase A signaling • establishment of centrosome localization • regulation of microvillus length • phosphatidylinositol-mediated signaling • regulation of cell size • actin cytoskeleton reorganization • filopodium assembly • receptor internalization • terminal web assembly • axon guidance • positive regulation of gene expression • cellular protein complex localization • negative regulation of ERK1 and ERK2 cascade • establishment of protein localization to plasma membrane • protein localization to cell cortex Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7430	22350
Ensembl	ENSG00000092820	ENSMUSG00000052397
UniProt	P15311	P26040
RefSeq (mRNA)	NM_001111077 NM_003379	NM_009510
RefSeq (protein)	NP_001104547.1 NP_003370.2	NP_033536.2
Location (UCSC)	Chr 6: 158.77 – 158.82 Mb	Chr 17: 6.74 – 6.78 Mb
PubMed search	[1]	[2]
Wikidata

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.^[3]

Structure

The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain.

Function

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.^[4]

The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery).^[5] The C-terminal binds to actin, phosphatidylinositol(4,5)bis-phosphate (PIP2)^[6] and membrane proteins like CD44 and ICAM-2.

Interactions

VIL2 has been shown to interact with:

References

Further reading

PDB gallery
1ni2: Structure of the active FERM domain of Ezrin