Extra-amniotic administration

Extra-amniotic administration is a route of administration to the space between the fetal membranes and endometrium inside the uterus of a pregnant woman.

It can be used to administer drugs affecting uterus motility, such as oxytocin and prostaglandins, e.g. in labor induction or medical abortion.[1]


It can be performed using a catheter with a balloon that is inserted under direct vision through the cervix. The balloon is inflated with 30 ml of sterile water, allowing medication to be injected through the catheter into the extra-amniotic space.[2]


  1. Gómez Ponce de León R, Wing DA (April 2009). "Misoprostol for termination of pregnancy with intrauterine fetal demise in the second and third trimester of pregnancy - a systematic review". Contraception. 79 (4): 259–71. doi:10.1016/j.contraception.2008.10.009. PMID 19272495.
  2. A Comparative Study of Extra-Amniotic Infusion of Corticosteroids versus Normal Saline for Induction of Labour. K. Pushpalatha M.B.B.S, M.S (OBG). The Internet Journal of Third World Medicine. 2009 Volume 8 Number 1.
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