Ehrlich ascites carcinoma

Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. It was originally established as an ascites tumor in mice.

Ehrlich cell

The tumor was cultured in vivo, which became known as the Ehrlich cell.[1] After 1948 Ehrlich cultures spread around research institutes all over the world. The effusion contained neoplastic cells that are proliferated after injection of tumor cells into the peritoneal cavity is known as ascites.[2] The Ehrlich cell became popular because it could be expanded by in vivo passage. This made it useful for biochemical studies involving large amounts of tissues. It could also be maintained in vitro for more carefully controlled studies. Culture techniques in large-scale, mice passage is less attractive, due to the contamination of the tumor with multifarious host inflammatory cells.[1] EAC has a similarity with human tumors that are most sensitive to chemotherapy due to its rapid growth rate.[2]

Properties

EAC is referred to as undifferentiated carcinoma, and is originally hyper-diploid. It is highly transplantable, no regression, rapid proliferation and shorter life span, 100% malignancy, and does not have tumor-specific transplantation.[2] The permeability to water is highest at the initiation of S and progressively decreases to its lowest value just after mitosis. Activation heats for water permeability vary during the cell cycle, ranging from 9–14 kca/mole.[3]

References

  1. 1 2 "Ehrlich Cells (Molecular Biology)". what-when-how.com. Retrieved 2016-04-22.
  2. 1 2 3 Ozaslan, Mehmet; Karagoz, Isik Didem; Kilic, Ibrahim Halil; Guldur, Muhammed Emin (March 2011). "Ehrlich Ascites Carcinoma" (PDF). African Journal of Biotechnology. 10 (13): 2375–2378. doi:10.5897/AJBx10.017 (inactive April 21, 2016). ISSN 1684-5315. Retrieved April 21, 2016.
  3. ↑ Dupre, Ann M.; Hempling, H. G. (December 1978). "Osmotic properties of ehrlich ascites tumor cells during the cell cycle". Journal of Cellular Physiology. 97 (3): 381–395. doi:10.1002/jcp.1040970313. ISSN 1097-4652.

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