Clinical data
Trade names Landel (ランデル)
AHFS/Drugs.com International Drug Names
Routes of
ATC code none
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 111011-63-3 YesY
PubChem (CID) 119171
ChemSpider 106463 N
Chemical and physical data
Formula C34H38N3O7P
Molar mass 631.65 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Efonidipine (INN) is a dihydropyridine calcium channel blocker marketed by Shionogi & Co. of Japan. It was launched in 1995, under the brand name Landel (ランデル). The drug blocks both T-type and L-type calcium channels.[1]

It has also been studied in atherosclerosis[2] and acute renal failure.[3]


  1. Tanaka H, Shigenobu K (2002). "Efonidipine hydrochloride: a dual blocker of L- and T-type Ca2+ channels". Cardiovasc. Drug Rev. 20 (1): 81–92. PMID 12070536.
  2. Toyoda K, Kitahara M, Yamashita T, et al. (May 1994). "[Effect of efonidipine hydrochloride (NZ-105), a new dihydropyridine calcium antagonist, on the experimental atherosclerosis in cholesterol-fed rabbits]". Nippon Yakurigaku Zasshi (in Japanese). 103 (5): 231–9. PMID 8188119.
  3. Shudo C, Masuda Y, Sugita H, Tanaka S, Tomita K (November 1994). "Effects of efonidipine hydrochloride (NZ-105), a new calcium antagonist, against acute renal failure in rats". Gen. Pharmacol. 25 (7): 1451–8. PMID 7896060.

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