eEF-1

eEF-1 is a eukaryotic elongation factor.

Its α and βγ subunits act as counterparts to EF-Tu and EF-Ts, respectively

Genes include:

• EEF1A1, EEF1A2, EEF1A3
• EEF1B1, EEF1B2, EEF1B3, EEF1B4
• EEF1D, EEF1E1, EEF1G

Various species of green algae, red algae, chromalveolates, and fungi lack the EF-1α gene but instead possess a related gene called EFL (elongation factor-like). Although its function has not been studied in depth, it appears to be similar to EF-1α.

Only two organisms are known to have both EF-1α and EFL: the fungus Basidiobolus and the diatom Thalassiosira. The evolutionary history of EFL is unclear. It may have arisen one or more times followed by loss of EFL or EF-1α. The presence in three diverse eukaryotic groups (fungi, chromalveolates, and archaeplastida) is supposed to be the result of two or more horizontal gene transfer events.^[1]

References

1. ↑ Ellen Cocquyt; Heroen Verbruggen; Frederik Leliaert; Frederick W Zechman; Koen Sabbe; Olivier De Clerck (2009), "Gain and loss of elongation factor genes in green algae", BMC Evol Biol., 9: 39, doi:10.1186/1471-2148-9-39, PMC 2652445, PMID 19216746 

External links

• Peptide Elongation Factor 1 at the US National Library of Medicine Medical Subject Headings (MeSH)