Endothelin 1

EDN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EDN, 1EDP, 1T7H, 1V6R
Identifiers
Aliases	EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME, endothelin 1
External IDs	MGI: 95283 HomoloGene: 1476 GeneCards: EDN1
Gene ontology Molecular function • hormone activity • receptor binding • cytokine activity • endothelin B receptor binding • protein binding • endothelin A receptor binding Cellular component • cytoplasm • Weibel-Palade body • basal part of cell • extracellular region • extracellular space • rough endoplasmic reticulum lumen Biological process • skeletal system development • response to amino acid • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • negative regulation of cellular protein metabolic process • positive regulation of MAP kinase activity • regulation of sensory perception of pain • vasoconstriction • body fluid secretion • positive regulation of sarcomere organization • positive regulation of cardiac muscle hypertrophy • cell surface receptor signaling pathway • cellular response to drug • multicellular organism aging • artery smooth muscle contraction • cellular response to interferon-gamma • positive regulation of chemokine-mediated signaling pathway • phosphatidylinositol 3-kinase signaling • response to leptin • positive regulation of mitotic nuclear division • cellular response to hypoxia • response to muscle stretch • cellular response to calcium ion • cellular response to transforming growth factor beta stimulus • regulation of blood vessel size • positive regulation of renal sodium excretion • blood vessel morphogenesis • negative regulation of blood coagulation • response to nicotine • in utero embryonic development • neutrophil chemotaxis • cell growth • heart development • positive regulation of prostaglandin secretion • vein smooth muscle contraction • cartilage development • rhythmic excitation • protein kinase C-activating G-protein coupled receptor signaling pathway • cellular response to glucocorticoid stimulus • negative regulation of cAMP biosynthetic process • branching involved in blood vessel morphogenesis • negative regulation of hormone secretion • positive regulation of smooth muscle contraction • negative regulation of nitric-oxide synthase biosynthetic process • positive regulation of prostaglandin-endoperoxide synthase activity • G-protein coupled receptor signaling pathway • positive regulation of urine volume • positive regulation of JUN kinase activity • leukocyte activation • positive regulation of receptor biosynthetic process • membrane depolarization • negative regulation of transcription from RNA polymerase II promoter • response to ozone • respiratory gaseous exchange • positive regulation of heart rate • regulation of blood pressure • response to lipopolysaccharide • response to prostaglandin F • regulation of vasoconstriction • cellular response to interleukin-1 • response to salt • positive regulation of cell size • middle ear morphogenesis • sensory perception of pain • prostaglandin biosynthetic process • dorsal/ventral pattern formation • phospholipase D-activating G-protein coupled receptor signaling pathway • positive regulation of odontogenesis • regulation of pH • positive regulation of smooth muscle cell proliferation • protein kinase C deactivation • histamine secretion • maternal process involved in parturition • intracellular signal transduction • response to hypoxia • neural crest cell development • regulation of systemic arterial blood pressure by endothelin • nitric oxide transport • positive regulation of cell migration • response to testosterone • positive regulation of cytosolic calcium ion concentration • epithelial fluid transport • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • cellular response to tumor necrosis factor • response to activity • response to dexamethasone • superoxide anion generation • positive regulation of endothelial cell migration • cellular response to peptide hormone stimulus • cellular response to fatty acid • peptide hormone secretion • cellular response to mineralocorticoid stimulus • positive regulation of cell proliferation • inositol phosphate-mediated signaling • positive regulation of hormone secretion • negative regulation of smooth muscle cell apoptotic process • response to drug • glucose transport • calcium-mediated signaling • response to transforming growth factor beta • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of cell growth involved in cardiac muscle cell development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1906	13614
Ensembl	ENSG00000078401	ENSMUSG00000021367
UniProt	P05305	P22387
RefSeq (mRNA)	NM_001168319 NM_001955	NM_010104
RefSeq (protein)	NP_001161791.1 NP_001946.3	NP_034234.1
Location (UCSC)	Chr 6: 12.29 – 12.3 Mb	Chr 13: 42.3 – 42.31 Mb
PubMed search	[1]	[2]
Wikidata

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin.

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.^[3]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.