Venombin A
| Venombin A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.74 | ||||||||
| CAS number | 146240-35-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Venombin A (EC 3.4.21.74, alpha-fibrinogenase, habutobin, zinc metalloproteinase Cbfib1.1, zinc metalloproteinase Cbfib1.2, zinc metalloproteinase Cbfib2, ancrod) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Selective cleavage of Arg- bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme
This enzyme is a thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group.
References
- ↑ Nolan, C.; Hall, L.S.; Barlow, G.H. (1976). "Ancrod, the coagulating enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom". Methods Enzymol. 45: 205–213. doi:10.1016/s0076-6879(76)45020-6. PMID 1011992.
- ↑ Stocker, K.; Barlow, G.H. (1976). "The coagulant enzyme from Bothrops atrox venom (batroxobin)". Methods Enzymol. 45: 214–223. doi:10.1016/s0076-6879(76)45021-8. PMID 1011993.
- ↑ Markland, F.S.; Kettner, C.; Schiffmann, S.; Shaw, E.; Bajwa, S.S.; Reddy, K.N.N.; Kirakossian, H.; Patkos, G.B.; Theodor, I.; Pirkle, H. (1982). "Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen". Proc. Natl. Acad. Sci. USA. 79: 1688–1692. doi:10.1073/pnas.79.6.1688. PMID 7043462.
- ↑ Simmons, G.; Bundalian, M.; Theodor, I.; Martinoli, J.; Pirkle, H. (1985). "Action of crotalase, an enzyme with thrombin-like and kallikrein-like specificities, on tripeptide nitroanilide derivatives". Thromb. Res. 40: 555–561. doi:10.1016/0049-3848(85)90292-0. PMID 2934864.
- ↑ Itoh, N.; Tanaka, N.; Funakoshi, I.; Kawasaki, T.; Mihashi, S.; Yamashina, I. (1988). "Organisation of the gene for batroxobin, a thrombin-like snake venom enzyme. Homology with the trypsin/kallikrein gene family". J. Biol. Chem. 263: 7628–7631. PMID 3163691.
External links
- Venombin A at the US National Library of Medicine Medical Subject Headings (MeSH)
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