Double-stranded uracil-DNA glycosylase
| Double-stranded uracil-DNA glycosylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.2.28 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Double-stranded uracil-DNA glycosylase (EC 3.2.2.28, Mug, double-strand uracil-DNA glycosylase, Dug, dsUDG, double-stranded DNA specific UDG, dsDNA specific UDG, UdgB, G:T/U mismatch-specific DNA glycosylase, UDG) is an enzyme with systematic name uracil-double-stranded DNA deoxyribohydrolase (uracil-releasing).[1][2][3] This enzyme catalyses the following chemical reaction
- Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil
This enzyme is not active on DNA containing a T/G mispair or single-stranded DNA.
References
- ↑ Barrett, T.E.; Scharer, O.D.; Savva, R.; Brown, T.; Jiricny, J.; Verdine, G.L.; Pearl, L.H. (1999). "Crystal structure of a thwarted mismatch glycosylase DNA repair complex". EMBO J. 18: 6599–6609. doi:10.1093/emboj/18.23.6599. PMID 10581234.
- ↑ Sung, J.S.; Mosbaugh, D.W. (2000). "Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV". Biochemistry. 39: 10224–10235. doi:10.1021/bi0007066. PMID 10956012.
- ↑ Mokkapati, S.K.; Fernandez de Henestrosa, A.R.; Bhagwat, A.S. (2001). "Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells". Mol. Microbiol. 41: 1101–1111. doi:10.1046/j.1365-2958.2001.02559.x. PMID 11555290.
External links
- Double-stranded uracil-DNA glycosylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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