Delta12-fatty-acid desaturase
| Delta12-fatty-acid desaturase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.19.6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Delta12-fatty-acid desaturase (EC 1.14.19.6, Delta12 fatty acid desaturase, Delta12(omega6)-desaturase, oleoyl-CoA Delta12 desaturase, Delta12 desaturase, Delta12-desaturase) is an enzyme with systematic name acyl-CoA,hydrogen donor:oxygen Delta12-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- acyl-CoA + reduced acceptor + O2 Delta12-acyl-CoA + acceptor + 2 H2O
In the yeast Lipomyces starkeyi and in the American cockroach, this microsomal enzyme converts oleoyl-CoA into linoleoyl-CoA.
References
- ↑ Borgeson, C.E.; de Renobales, M.; Blomquist, G.J. (1990). "Characterization of the Δ12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate". Biochim. Biophys. Acta. 1047: 135–140. doi:10.1016/0005-2760(90)90039-z. PMID 2248971.
- ↑ Jurenka, R.A. (1997). "Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a Δ12 desaturase". Cell. Mol. Life Sci. 53: 501–505. doi:10.1007/s000180050062. PMID 9230926.
- ↑ Lomascolo, A.; Dubreucq, E.; Galzy, P. (1996). "Study of the Δ12-desaturase system of Lipomyces starkeyi". Lipids. 31: 253–259. doi:10.1007/bf02529871. PMID 8900454.
- ↑ Tocher, D.R.; Leaver, M.J.; Hodgson, P.A. (1998). "Recent advances in the biochemistry and molecular biology of fatty acyl desaturases". Prog. Lipid Res. 37: 73–117. doi:10.1016/s0163-7827(98)00005-8. PMID 9829122.
External links
- Delta12-fatty-acid desaturase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/17/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.