DGAT1

DGAT1
Identifiers
Aliases DGAT1, ARAT, ARGP1, DGAT, DIAR7, diacylglycerol O-acyltransferase 1
External IDs MGI: 1333825 HomoloGene: 7688 GeneCards: DGAT1
EC number 2.3.1.76
Orthologs
Species Human Mouse
Entrez

8694

13350

Ensembl

ENSG00000185000

ENSMUSG00000022555

UniProt

O75907

Q9Z2A7

RefSeq (mRNA)

NM_012079

NM_010046

RefSeq (protein)

NP_036211.2

NP_034176.1

Location (UCSC) Chr 8: 144.31 – 144.33 Mb Chr 15: 76.5 – 76.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Diacylglycerol O-acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene.[3]

Function

This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.[4]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Diacylglycerol O-acyltransferase 1". Retrieved 2016-08-28.
  4. ↑ Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008). "Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis". Journal of Lipid Research. 49 (11): 2283–301. doi:10.1194/jlr.R800018-JLR200. PMC 3837458Freely accessible. PMID 18757836.

Further reading

  • Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV (July 2002). "DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women". Clinical Genetics. 62 (1): 68–73. PMID 12123490. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the 8/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.