Cytochrome b5 reductase
| cytochrome-b5 reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC number | 1.6.2.2 | ||||||||
| CAS number | 9032-25-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
Cytochrome-b5 reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:
NADH + H+ + 2 ferricytochrome b5 = NAD+ + 2 ferrocytochrome b5
The following four human genes encode cytochrome-b5 reductases:
See also
External links
- Cytochrome-B(5) Reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
- PDB: 1IB0 - crystal structure of rat CBR complexed with NAD
- PDB: 1NDH - crystal structure of pig liver CBR
- PDB: 1UMK - crystal structure of human erythrocyte CBR
- InterPro: IPR001834 - InterPro entry for CBR
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