Cytidine triphosphate

Cytidine triphosphate
Skeletal formula of cytidine triphosphate as an anion (3- charge)
Space-filling model of the cytidine triphosphate molecule as an anion (4- charge)
IUPAC name
[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl(hydroxy-phosphonooxyphosphoryl)hydrogen phosphate
Other names
CTP; Cytidine-5'-triphosphate; Cytidine 5'-(tetrahydrogen triphosphate)
65-47-4 YesY
3D model (Jmol) Interactive image
Interactive image
ChemSpider 19952488 YesY
ECHA InfoCard 100.000.556
MeSH Cytidine+triphosphate
PubChem 6176
Molar mass 483.156
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Cytidine triphosphate is a pyrimidine nucleoside triphosphate.

CTP, much like ATP, consists of a ribose sugar, and three phosphate groups. The major difference between the two molecules is the base used, which in CTP is cytosine.

CTP is a substrate in the synthesis of RNA.

CTP is a high-energy molecule similar to ATP, but its role as an energy coupler is limited to a much smaller subset of metabolic reactions. CTP is a coenzyme in metabolic reactions like the synthesis of glycerophospholipids and glycosylation of proteins.

CTP acts as an inhibitor of the enzyme Aspartate carbamoyltransferase, which is used in pyrimidine biosynthesis.[1]

See also


  1. Blackburn, G. Michael. Nucleic Acids in Chemistry and Biology. The Royal Society of Chemistry, 2006, p. 119-120.
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