Cyclin K

CCNK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2I53, 4CXA, 4NST, 4UN0, 5EFQ, 5ACB

Identifiers

Aliases

CCNK, CPR4, Cyclin K

External IDs

MGI: 1276106 HomoloGene: 14748 GeneCards: CCNK

Gene ontology
Molecular function	• protein binding • protein kinase binding • RNA polymerase II carboxy-terminal domain kinase activity • cyclin-dependent protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • protein serine/threonine kinase activity
Cellular component	• cyclin K-CDK12 complex • nucleus • cyclin K-CDK13 complex • nucleoplasm
Biological process	• positive regulation of cyclin-dependent protein serine/threonine kinase activity • transcription elongation from RNA polymerase II promoter • mitotic nuclear division • regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues • negative regulation of cell cycle arrest • regulation of transcription, DNA-templated • cellular response to DNA damage stimulus • transcription from RNA polymerase II promoter • negative regulation by host of viral genome replication • positive regulation of transcription from RNA polymerase II promoter • cell division • cell cycle • protein phosphorylation • transcription, DNA-templated • snRNA transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8812


12454

Ensembl


ENSG00000090061


ENSMUSG00000021258

UniProt


O75909


O88874

RefSeq (mRNA)


NM_001099402 NM_003858


NM_009832

RefSeq (protein)


NP_001092872.1


n/a

Location (UCSC)

Chr 14: 99.48 – 99.54 Mb

Chr 12: 108.18 – 108.2 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclin-K is a protein that in humans is encoded by the CCNK gene.^[3]^[4]^[5]

Function

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.^[5]

Interactions

Cyclin K has been shown to interact with CDK9.^[4] Cyclin K also interacts with HIV nef protein.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity". Molecular and Cellular Biology. 18 (7): 4291–300. PMC 109013. PMID 9632813.
1 2 Fu TJ, Peng J, Lee G, Price DH, Flores O (Dec 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". The Journal of Biological Chemistry. 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912.
1 2 "Entrez Gene: CCNK cyclin K".
↑ Khan SZ, Mitra D (Jul 2011). "Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner". The Journal of Biological Chemistry. 286 (26): 22943–22954. doi:10.1074/jbc.M110.201194. PMID 21555514.

Lin X, Taube R, Fujinaga K, Peterlin BM (May 2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". The Journal of Biological Chemistry. 277 (19): 16873–8. doi:10.1074/jbc.M200117200. PMID 11884399.
Mori T, Anazawa Y, Matsui K, Fukuda S, Nakamura Y, Arakawa H (2002). "Cyclin K as a direct transcriptional target of the p53 tumor suppressor". Neoplasia. 4 (3): 268–74. doi:10.1038/sj/neo/7900235. PMC 1531701. PMID 11988847.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Baek K, Brown RS, Birrane G, Ladias JA (Feb 2007). "Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9". Journal of Molecular Biology. 366 (2): 563–73. doi:10.1016/j.jmb.2006.11.057. PMC 1852425. PMID 17169370.

PDB gallery

2i53: Crystal structure of Cyclin K

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Cyclin K

Function

Interactions

References

Further reading