Cyclin-dependent kinase inhibitor protein

This article is about the cell cycle protein. For the medical therapy, see CDK inhibitor.
Cyclin-dependent kinase inhibitor

Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1]
Symbol CDI
Pfam PF02234
InterPro IPR003175
SCOP 1jsu

A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor suppressor genes. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G1 phase.


Protein Gene Interacts with
p16CDKN2ACyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15CDKN2BCyclin-dependent kinase 4
p18CDKN2CCyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19CDKN2DCyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1CDKN1A[2]Cyclin E1/Cyclin-dependent kinase 2
p27CDKN1BCyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57CDKN1CCyclin E1/Cyclin-dependent kinase 2
CDKN3Cyclin-dependent kinase 2


  1. Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
  2. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.

External links

This article is issued from Wikipedia - version of the 5/24/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.