Cooperative Human Tissue Network

The Cooperative Human Tissue Network (the CHTN) was established in 1987 by the National Cancer Institute in response to an increase in the demand for high quality biospecimens for cancer research. The purpose of the CHTN is to stimulate, for the good of the public, cooperative efforts to collect and distribute human biospecimens and to thereby facilitate research utilizing those specimens. These activities are expected to encourage basic and developmental studies in many areas of cancer research, including molecular biology, immunology and genetics. The CHTN is not intended to be a human tissue bank but may use limited banking as needed to meet specific requests and longer-term banking of targeted specimens to assure availability of rare and hard to obtain materials.

The CHTN has six divisions, five adult divisions and one pediatric division. These divisions are located at the following institutions:

CHTN biospecimens

The CHTN obtains biospecimens from routine diagnostic or therapeutic surgical resections and autopsies, which otherwise would be discarded. Malignant, benign, diseased and normal biospecimens are collected and distributed to both national and international investigators. In addition, remnant body fluids are available on some patients and limited histological services can be obtained by special arrangement. Requests for large sample sizes, large numbers of biospecimens, rare biospecimens or biospecimens in high demand may be served if they do not negatively impact the availability of biospecimens for other researchers.

Investigators who wish to receive CHTN biospecimens

Investigators must complete a standard CHTN application which includes a brief description of their research project, funding information, and biospecimen requirements. In addition, a researcher must submit documentation of his/her Institutional Review Board (IRB) approval or exemption.

Use of CHTN biospecimens

The intent of the CHTN is to encourage research using human biospecimens for the good of the public rather than for private gain. The CHTN Agreement for Use of Tissue, which must be signed by all CHTN investigators, states “The recipient agrees that it shall not sell any portion of the tissues provided by the CHTN, or products directly extracted from these tissues (e.g. protein, mRNA or DNA). The recipient agrees that it shall not transfer tissue (or any portion thereof) supplied by the CHTN to third parties without the prior written permission of the CHTN.”

Policies and procedures for the protection of human subjects

The CHTN has established operating policies and procedures that protect the subjects from whom CHTN biospecimens are obtained. These policies and procedures are consistent with current regulations and guidance for repositories from the Office of Human Research Protections (OHRP) in the Department of Human and Health Services (DHHS), The following policies and procedures govern collection of biospecimens and their distribution to researchers:

The CHTN is aware of and actively participates in national discussions of the legal and ethical issues relating to the research use of human specimens. The CHTN continues to review its procedures for compliance with applicable regulations and for consistency with any emerging consensus about the ethical collection and use of specimens for research.

See also

External links

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