Not to be confused with Colostrum.

Coronal section of human Cerebrum. Claustrum is pointed by the arrow.

Transverse section of human Cerebrum. Claustrum is pointed by the arrow.
MeSH A08.186.211.730.885.105
NeuroNames hier-234
NeuroLex ID Claustrum
TA A14.1.09.421
FMA 76440

Anatomical terms of neuroanatomy

The claustrum is a thin, irregular, sheet of neurons that is attached to the underside of the neocortex in the center of the brain. It is suspected to be present in the brains of all mammals.

The claustrum is a fraction of a millimetre to a few millimetres deep and is a vertical curved sheet of subcortical gray matter oriented sagittally between the white matter tracts of the external capsule and extreme capsule. The claustrum is lateral to the putamen and medial to the insular cortex and is considered by some sources to be part of the basal ganglia. There are lateral and medial tracts connecting the claustrum to many parts of the cortex and perhaps to the hippocampus, the amygdala, and the caudate nucleus (connections with subcortical centers are a matter of debate).

One of the interesting features of the claustrum is the uniformity in the types of cells, indicating a uniform type of processing by all claustral neurons. Though organized into modality specific regions, the claustrum contains a great deal of longitudinal connections between its neurons that could serve to synchronize the entire anterior-posterior extent of the claustrum.[1] Francis Crick and Christof Koch have compared the claustrum to the conductor of an orchestra, referring to its regulatory role in consciousness and cognition.[2] The different parts of the cortex must play in harmony or else the result is a cacophony of sounds instead of a beautiful symphony. The claustrum may be involved in widespread coordination of the cerebral cortex, using synchronization to achieve a seamless timescale between both the two cortical hemispheres and between cortical regions within the same hemisphere, resulting in the seamless quality of conscious experience.


The claustrum is a telencephalic subcortical structure. It is a thin sheet of grey matter underneath the inner part of the neocortex. It is on both sides of the brain, and can be found below the insular cortex, which deep to the temporal and parietal lobes at the deepest point of the lateral fissure, and above the outside of the putamen, which is a sub-structure of the basal ganglia. The sheet is approximately one to several millimeters thick, and can cover up to a couple centimeters length wise depending on the animal.

One interesting aspect about the claustrum is the paucity of cell types. In most parts of the brain, especially in the cortical regions, there is considerable differentiation of cell types, giving way to a number of functions. In the claustrum, as Dr. Crick and others pointed out, there are three main types of cells.[3] The first, which is deemed Type 1, is large with spine-covered dendritic processes. These cells receive input as well as project back toward various regions, both laterally and medially. The other two types of cells do not have spines, but can be told apart based on the cell body size. However, both are restricted to the claustrum and, thus, are labeled interneurons.

It is clear that the claustrum projects to, and receives projections from, a number of cortices, including the primary motor, premotor, prefrontal, auditory, and visual, among others. In one study conducted in France by Judith Tanne-Gariepy et al. (9), these projections were traced back to segregated areas, including differentiated areas along the dorsoventral axis for the pre-supplementary motor area and supplementary motor area – proper. Projections from the claustrum to various sub-regions of the motor cortex were shown to overlap somewhat, but did show a degree of local segregation.[4][5] The truly interesting thing about the claustrum, however, is how it can take in multiple information modalities, including motor, visual, and auditory. It has even been shown that the same cells can process information across all these types, even though there is some semblance of segregation across a single type of information.

There have also been a number of interesting studies looking at the proteins inside the claustrum. In one experiment performed at the University of South Carolina by J.R. Augustine et al.,[6] researchers looked at calcium-binding proteins in the rhesus monkey claustrum, including calbindin D28K, parvalbumin, and calretinin. After removing the brains and properly preserving them, the group used various antibodies and antiserums to detect the presence of the proteins. The calbindin proteins were shown as likely elements in the inhibitory circuitry of the claustrum, while the calretinin most likely served as calcium buffer to maintain homeostasis. Another study looked at the serotonergic innervation in the claustrum.[7] The clear conclusion here was that, in the ventral claustrum where the visual projections are, the stained axons were short and arranged randomly. However, in the dorsal, non-visual section, of the claustrum, the fibers ran consistently in long lengths along the dorsal-ventral direction. Like many of the other studies, this is a good first step toward determining the true functions of the claustrum, although there is still much room for work.


Very little is known about the actual function of the claustrum. Anatomical hindrances combined with a lack of case studies have left many holes in the research on the claustrum. For these reasons, systematic studies of the claustrum have been sparse.

Although the exact function of the claustrum remains to be verified, connectivity studies have shown that the claustrum plays a strong role in communication between the two hemispheres of the brain, specifically between cortical regions controlling attention.[1] The precise role of these interhemispheric circuits is not yet understood, but one goal could be to create a common timescale between the two hemispheres, which might help to achieve a seamless unity of attention/consciousness between processing in each hemisphere. Other interhemispheric connections could also play a role in this process.

Clinical evidence has suggested that the claustrum plays an important role in maintaining consciousness, potentially being usable as an "on-off switch". In 2014 the case of one woman was reported who fell unconscious when her claustrum was electrically stimulated and regained consciousness as soon as the stimulation stopped.[8][9]

Integration of modalities

A number of different studies, summed up succinctly by Crick and Koch, have suggested that the claustrum is essential in multisensory integration. Objects in real life have many different characteristics, such as sound, shape, color, speed, and smell. For example, the subject might both see a bird and hear it chirping, where the combination of visual and auditory stimuli will be perceived as being from the same source. We need to take in all of this information and integrate it correctly to perceive a single object. "Binding" of various sensory modalities is essential to merge all the information of a single stimulus into a single percept. Crick and Koch suggest the claustrum might be involved in neural processes sub-serving perceptual binding.[10] This theory remains highly controversial, however, and it would be inaccurate to say that there is any established biological explanation for the function of the claustrum.

Despite this hypothesis by Crick and Koch, a recent study in primates has shown that claustrum does not seem to be integrating information from multiple sensory modalities, but instead contains separated unimodal processing regions.[11] Furthermore, the role of the claustrum in sensorimotor integration has also been called into question, at least in rodents.[12] Thus, the function of the claustrum remains a mystery.


The claustrum has been studied for nearly two centuries.[13] Historically, many researchers have viewed it as an interesting structure that could hold the key to a number of neuroscientific questions. The claustrum has a phylogenetic background appearing predominantly in insectivores, strepsirrhine primates, and marsupials. It is difficult to trace where the evolution of the structure originated.

One big point of discussion with regard to the claustrum has been on the ontogeny. One side, which Dr. Edelstein deems the pallial group, believes the claustrum is a derivative of the insular cortex. While some designated this as a certain distinguished area not to be confused with the rest of the cortex, they still ascertained that the ontogeny was based on the development of the cortex. The other side states that the claustrum is derived from basal ganglia. Ramon y Cajal supported this latter theory, as did many other researchers.[14] Based on more recent methods of looking at the development of both the human and animal mind, including fMRI among others, there has been increasing evidence against the claustrum being a part of the cortex. They seem to have distinct developmental periods and are, therefore, deemed separate structures. The third theory, which is supported by the majority at present, says that the claustrum is neither distinctly part of the cortex nor from the basal ganglia complex. Based on a number of studies, including those that show projections on both sides of the claustrum, many believe the claustrum should be considered a seventh layer of the cortex, in the insular region.[4] This hypothesis, which is growing support, including the aforementioned Dr. Larry Edelstein, is labeled as Filiminoff's hypothesis since he was estimated to be the first to come to this conclusion [5]

As far as historical cases shedding light on the anatomy and function of the claustrum is concerned, there have not been many to date that survived the struggle of time. There was one documented case on an enlarged claustrum in a patient with epilepsy, as well as another case in which the insula was malformed but the claustrum remained. These cases have not lent very much toward the pursuit of truth regarding the claustrum. At this point in time, pathology involved with the claustrum remains unknown. Also, due to the location and complex integration of the claustrum with other parts of the brain, it is difficult to do lesion studies without affecting other regions. Likewise, ablation is not an effective option, either. Most studies involve either the removal and preservation of the brain or in vivo scanning of the area of interest during different studies. This could involve fMRI, the newer Tractography technology, or others.


The name "claustrum" comes from Latin [ME. cloistre, a. OF. cloistre, earlier clostre:—L. claustr-um, clōstr-um, ‘a bar, bolt, lock’, later ‘a shut up place, a cloister’, f. claud-, claus- to shut + -trum instrumental suffix. Before the adoption of the French form, OE. had already clauster and clústor from Latin, and ME. had also closter, and clowster.] .[15]

Additional images


  1. 1 2 Smith, J. B.; Alloway, K. D. (2010). "Functional Specificity of Claustrum Connections in the Rat: Interhemispheric Communication between Specific Parts of Motor Cortex". Journal of Neuroscience. 30 (50): 16832–44. doi:10.1523/JNEUROSCI.4438-10.2010. PMC 3010244Freely accessible. PMID 21159954.
  2. Koubeissi, M. Z.; Bartolomei, F. (2014). "Electrical stimulation of a small brain area reversibly disrupts consciousness". Epilepsy & Behavior. 37: 32–35. doi:10.1016/j.yebeh.2014.05.027. PMID 24967698.
  3. Rahman, Fahad E.; Baizer, Joan S. (2007). "Neurochemically defined cell types in the claustrum of the cat". Brain Research. 1159: 94–111. doi:10.1016/j.brainres.2007.05.011. PMID 17582386.
  4. 1 2 Tanné-Gariépy, Judith; Boussaoud, Driss; Rouiller, Eric M. (2002). "Projections of the claustrum to the primary motor, premotor, and prefrontal cortices in the macaque monkey". The Journal of Comparative Neurology. 454 (2): 140–57. doi:10.1002/cne.10425. PMID 12412139.
  5. 1 2 Fernández-Miranda, Juan C.; Rhoton, Albert L.; Kakizawa, Yukinari; Choi, Chanyoung; Álvarez-Linera, Juan (2008). "The claustrum and its projection system in the human brain: A microsurgical and tractographic anatomical study". Journal of Neurosurgery. 108 (4): 764–74. doi:10.3171/JNS/2008/108/4/0764. PMID 18377257.
  6. Augistine JR. Calcium-binding proteins in the claustrum of the rhesus monkey. 2008. Society for Neuroscience. Program#/Poster#: 79.9/OO31
  7. Baizer, J.S (2001). "Serotonergic innervation of the primate claustrum". Brain Research Bulletin. 55 (3): 431–4. doi:10.1016/S0361-9230(01)00535-4. PMID 11489351.
  8. Helen Thomson (2 July 2014). "Consciousness on-off switch discovered deep in brain". New Scientist. Retrieved 2014-07-04.
  9. Koubeissi, Mohamad Z.; Bartolomei, Fabrice; Beltagy, Abdelrahman; Picard, Fabienne (Aug 2014). "Electrical stimulation of a small brain area reversibly disrupts consciousness". Epilepsy & Behavior. 37: 32–35. doi:10.1016/j.yebeh.2014.05.027. PMID 24967698.
  10. Crick, Francis; Koch, Christof (2005). "What is the function of the claustrum?". Philosophical Transactions of the Royal Society B: Biological Sciences. 360 (1458): 1271–9. doi:10.1098/rstb.2005.1661. PMC 1569501Freely accessible. PMID 16147522.
  11. Remedios, R.; Logothetis, N. K.; Kayser, C. (2010). "Unimodal Responses Prevail within the Multisensory Claustrum". Journal of Neuroscience. 30 (39): 12902–7. doi:10.1523/JNEUROSCI.2937-10.2010. PMID 20881109.
  12. Smith, J. B.; Radhakrishnan, H.; Alloway, K. D. (2012). "Rat Claustrum Coordinates but Does Not Integrate Somatosensory and Motor Cortical Information". Journal of Neuroscience. 32 (25): 8583–8. doi:10.1523/JNEUROSCI.1524-12.2012. PMC 3390683Freely accessible. PMID 22723699.
  13. Edelstein LR, Denaro FJ (September 2004). "The claustrum: a historical review of its anatomy, physiology, cytochemistry and functional significance". Cell. Mol. Biol. (Noisy-le-grand). 50 (6): 675–702. PMID 15643691.
  14. Mathur BN. A comparative analysis of claustrum anatomy. 2008. Society for Neuroscience. Program#/Poster#: 79.11/OO33
  15. "OED". OUP. Retrieved 2015-01-29.
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