Class C GPCR

7 transmembrane receptor (metabotropic glutamate family)
Symbol 7tm_3
Pfam PF00003
InterPro IPR000337
TCDB 9.A.14
OPM superfamily 6
OPM protein 4or2

The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro: IPR000162) and several additional receptors.[1]

Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length PMID 17266540. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors


Calcium-sensing receptor-related

GABAB receptors

Metabotropic glutamate receptors


Taste receptors




  1. Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets. 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.

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