Chloride potassium symporter

The potassium chloride symporter is a membrane transport protein that is present in the S3-segment of the renal proximal tubule[1] and in the neuron.[2] It functions in renal chloride reabsorption to transport chloride across the basolateral membrane.[1] The concentrations of K+ and Cl- ions are high inside the cell due to the activities of Na+-K+ pump and NKCC cotransporter, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and Cl- from the cell.

They can lower intracellular chloride concentrations below the electrochemical equilibrium potential.[2]

They are of solute carrier family 12.


Types of chloride potassium symporter are:

Each is encoded by a separate gene.

The preceding symporters are actually other types of ion pumps. Member 3, for instance, is the sodium-chloride symporter.


  1. 1 2 Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 780
  2. 1 2 "Entrez Gene: SLC12A5 solute carrier family 12, (potassium-chloride transporter) member 5". Retrieved 28 August 2013.

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